Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itr...

The cytotoxic effect of several synthetic nitrogen-containing heterocyclic compounds on cultures tumour and normal cells the calculation their ADME, QSAR, DFT pharmacological properties
 aim. purpose our work was to investigate influence some compounds, namely imidazole, aurones, triazole culture melanoma mouse B16, human glioma U251 HEK293 properties calculation.
 Materials methods. ...

Saraca indica is an important medicinal plant and the compounds present in this are very much helpful preventing various diseases. Therefore, aim of study was to investigate antioxidant activity vitro investigation S. extract on lead-induced toxicity HepG2 HEK293 cell lines. The assay performed by two methods such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzothiazoline-6-s...

because of antimicrobial, antioxidant, and anticancer potential, salvia chorassanica bunge (lamiaceae) has been considered as a popular herb in iranian traditional medicine. previous studies have shown remarkable cytotoxic properties of the methanol, n -hexane and dichloromethane extract of s. chorassanica on human cervical cancer cells. to seek the therapeutic potentials of s. chorassanica, th...

background: numerous molecules in papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. objective: numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few...

Abstract Background and Aims: The number of new cancer cases with considerable mortality is increasing worldwide. Since the inability of current therapies in treatment of patients and prevention the progress of tumors with fewer side effects, implementation of new methods is needed. Gene therapy has widespread systemic cytotoxic effects against tumor cells. Rotavirus NSP4 has been shown to...

BACKGROUND Prunus africana is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia. MATERIALS AND METHODS In this study, compounds from the leaves and bark of this plant were isolated and tested for their cytotoxicity and apoptosis induction in two human cancer cell lines (hepatocellular carcinoma (HepG2) and colorectal carcinoma (Caco-2)) and a non...