Hemoglobinopathies constitute a heterogeneous group of hereditary hemoglobin disorders characterized by either reduced (thalassemias) or defective (sickle cell disease) globin chain synthesis that results in chronic hemolytic anemia. They represent the most common monogenetic disorders in humans, and although traditionally confined to specific geographic areas and populations (the Mediterranean...

INTRODUCTION Hemoglobin disorders are classified into three main groups: structural variants, thalassemias (thal) and hereditary persistence of fetal hemoglobin (HPFH). OBJECTIVE. This study describes the types and frequencies of hemoglobinopathies from four states of the Pacific coast of Mexico (Jalisco, Colima, Nayarit and Michoacan). MATERIAL AND METHODS. We studied 1513 Mexican individuals ...

BACKGROUND Iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. Severe iron deposition in tissues leads to organ dysfunction. Many organs can be affected such as heart, liver, and endocrine organs. Cardiac failure and liver fibrosis are the consequent of Iron overload in transfusion dependent hemoglobinopathy. Magnetic Resonance I...

Background: Hemoglobinopathies are the most common life threatening, monogenic disorders in world. The causes of hemoglobinopathies sickle cell disease and thalassemia. Objectives: purpose this study is to investigate Impact upon Behaviors Adolescents Karbala City/ Iraq. Methods: cross-sectional with quantitative approach was carried out on 200 participants who were attending hereditary blood c...

hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly mediterranean and middle eastern countries. hemoglobinopathies include structural variants of hemoglobin (hb s, hb c, hbe,…) and thalassaemias which are inherited defects in the globin chains synthesis. the present study was conducted to determine the prevalence of h...

Hemoglobinopathies include qualitative and quantitative disorders of globin synthesis [abnormal hemoglobins (Hbs) and thalassemias, respectively] and comprise the most common inherited disorders of man worldwide. They occur in particularly high frequency in many of the developing countries as a result of selection by endemic malaria, where they can pose a significant public health problem [1]. ...

In 2021 the Brazilian society of stem cell transplantation and therapy published consensus guidelines regarding hematopoietic (HSCT) for hemoglobinopathies. No changes have been added thalassemia. HSCT with a matched sibling donor (MSD) or related cord blood is treatment choice young patients transfusion dependent Matched unrelated haploidentical HSCT, using bone marrow graft, are clinical opti...