The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-di...

Harris, P. L., Ames, S. R. & Brinkman, J. H. (1951). J. Amer. chem. Sac. 73, 1252. Harrison, G. F. (1956). Private communication. Henry, K. M. (1956). Private communication. Henry, K. M. & Thompson, S. Y. (1954). Milchwissenschaft, 9, 14. Henry, K. M., Kon, S. K., Mawson, E. H., Stanier, J. E. & Thompson, S.Y.(1949). Brit.J. Nutr .3 ,301. Ingle, D. J. & Griffith, J. Q. (1949). In The Rat in Lab...