To the Editor: An estimated ≈150 million persons (3% of the world population) are chronically infected with hepatitis C virus (HCV). This virus is the prototype of the genus Hepacivi-rus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world. Every year, 3–4 million persons become infected with HCV, and ≈350,000 die of this infection (1). Development of an HCV vaccin...

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

conclusions we confirm that in amol city and surrounding areas, the prevalence of true hcv infection is 0.05%, which is lower than that previously reported from iran. results the mean age of participants was 42.70 ± 17.10 years. of these participants, 57.2% (n = 3483) were male. anti-hcv antibody was positive in 12 individuals from which five were riba positive. three of these subjects were pcr...

Nonprimate hepacivirus (NPHV) is the closest known relative of hepatitis C virus (HCV) and its study could enrich our understanding of HCV evolution, immunity, and pathogenesis. High seropositivity is found in horses worldwide with ∼ 3% viremic. NPHV natural history and molecular virology remain largely unexplored, however. Here, we show that NPHV, like HCV, can cause persistent infection for o...

POLO-LIKE KINASE 1 (PLK1) REGULATES IFN INDUCTION BY MAVS Damien Vitour+, Stéphanie Dabo+, Malek Ahmadi Pour, Myriam Vilasco, Pierre-Olivier Vidalain, Yves Jacob, Mariana Mezel-Lemoine, Suzanne Paz, Meztli Arguello, Rongtuan Lin, Frédéric Tangy, John Hiscott and Eliane F. Meurs From Institut Pasteur, Unit of Hepacivirus and Innate Immunity, Laboratory of Viral Genomics and Vaccination, Unit of ...