Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely use...

One of the main challenges cardiovascular tissue engineering is development bioresorbable and compliant small-diameter vascular grafts (SDVG) for patients where autologous are not an option. In this work, electrospun bilayered SDVG based on blends poly(L-lactic acid) (PLLA) segmented polyurethane (PHD) were prepared evaluated. The inner layer these was surface-modified with heparin, following a...

Heparin-induced thrombocytopenia is a rare immune-mediated complication of heparin therapy, characterized by decrease in platelet count more than 50% the baseline. Typically occurs between 5 to 10 days after initiation heparin. Incidence United States ranges from 0.2% 3.0%, depending on population studied and diagnostic criteria used. HIT has been categorized into two types: type I II. While be...

by drawing blood through a heparin lock, patients can be protected from skin damages duo to repeated needle sticks. in addition, this procedure can assist to gain more precise results in laboratory test and to prevent further complications. probably, you have ever used a heparin lock in order to infusion of medicines but, it is possible that you never use of that for blood sampling. both two pr...

background deep venous thrombosis (dvt) is a major risk of morbidity and mortality in morbid obese patients underwent bariatric surgery. there are some controversies in different kind of prophylactic strategies for dvt in laparoscopic bariatric surgeries. unfractionated heparin (ufh) is an available and reversible anticoagulant used for dvt prophylaxis. objectives this study aimed to compare cl...

A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin esters is proposed. The was validated linearity, accuracy, and precision terms repeatability intralaboratory reproducibility. intended to characterize esters, which are intermediates synthesis low-molecular-weight via hydrolytic depolymerization high-molecular-weight heparin.

The goal of the current study is to enhance hemocompatibility polyethersulfone (PES) membranes using heparin immobilization. Heparin was immobilized covalently and via electrostatic interaction with positively charged PES surface (pseudo-zwitterionic (pZW) complex) investigate influence each method on membrane hemocompatibility. In situ synchrotron radiation micro-computed tomography (SR-µCT) i...

• Green and renewable cellulose nanocrystals were utilized for heparin recovery. Polycationic side chains grafted from nanocrystals. Instantaneous heparin-capture in biological conditions reduced recovery efforts. Selective heparin-recovery was achieved via salt concentration or pH adjustment. Significantly higher ability than Amberlite achieved. Heparin is one of the most important anticoagula...