We read with great interest the article by Bazinet et al, which describes their findings from a phase II study of combination therapy tenofovir, peginterferon-alfa (pegIFN), and nucleic acid polymers (NAPs) REP-2139 or 2165 in hepatitis B e antigen–negative chronic B.1 The addition either NAP induced strong surface antigen (HBsAg) declines, resulting HBsAg undetectability ?50% patients. A signi...

conclusions being a barber alone is not a potential risk factor for hbv infection, while hcv infection is still an occupational health hazards for barbers. we suggest more extensive case-control studies with regard to rates of hepatitis b and c markers among barbers in other iranian cities to assess the incidence of hepatitis b and c infections among this population. background hepatitis b viru...

A literature search was carried out to investigate the factors that influence the protective efficacy (PE) of hepatitis B vaccines when given to neonates of hepatitis B surface antigen and e antigen positive mothers. Hepatitis B vaccines with either high or low antigen doses are very effective in preventing chronic hepatitis B infection in neonates at risk, but there is evidence that with lower...

A quantitation procedure for hepatitis B core antigen (HBcAg) in serum without prior removal of antibodies to HBcAg is described. The virus nucleoprotein core was released from hepatitis B virus (HBV) particles by treatment with Nonidet P-40 detergent and allowed to form immune complexes with homologous antibodies to HBcAg present in the sera of HBV-infected individuals. After precipitation wit...

conclusions this study indicates that the rate of g1896a mutation at the pc region among hbeag negative patients, in the golestan province of iran, was similar to the average rate encountered in other parts of iran. the pc stop codon mutation was detected in 93.18% of hbeag negative patients. further studies with larger sample sizes are required to elucidate the exact role of these mutations in...

abstract background: hepatitis b virus (hbv) infection in patients who lack detectable hepatitis b surface antigen (hbsag) is called occult hepatitis b infection. such infections have been frequently identified in patients with chronic hepatitis cliver disease, but their prevalence is not known. methods: 207 patients with chronic hepatitis c who were hcv -rna and antihcv positive were studied f...

Background/Aim: Hepatitis B surface antigen(HBsAg) is routinely detected qualitatively in Hepatitis B Virus(HBV) infection where its persistence beyond 6 months defines chronic hepatitis B(CHB) infection. Hepatitis B e antigen (HBeAg) usually indicates active HBV replication and risk of transmission of infection. In spite of the emerging use of chemiluminescence based quantitative HBsAg assays ...

Immunoglobulin M (IgM) antibodies against hepatitis B core antigen (anti-HBc) and hepatitis A virus (anti-HAV) were determined in 41 cases of acute viral hepatitis. In sera positive for anti-HBc or anti-HAV, IgM was separated from IgG by reorienting sucrose gradient high-speed centrifugation, and the IgG- and IgM-containing serum fractions were tested for the presence of specific antibody by ra...

Without intervention, a pregnant woman who is a chronic hepatitis B carrier is at risk of transmitting hepatitis B and of her infant becoming a chronic carrier and having a significantly increased lifetime risk of developing liver cancer or cirrhosis. Hepatitis B vaccine and immunoglobulin reduce the risk of the baby becoming a carrier, but with only a short window period after birth to deliver...