black seed (nigella sativa) is considered as a biological response modifier. thymoquinone (tq) is the bioactive and the most abundant constituent of the volatile oil of this seed which has been shown to possess anti-inflammatory, antioxidant and anti-neoplastic effects. in this study, the effect of tq on hepg2 cell line was investigated in an attempt to identify its potential mechanism of actio...

context from the 1970s till the mid 1990s, hepatitis b was the most common etiological factor for hepatocellular carcinoma (hcc) in pakistan. afterwards, a shift in hcc etiology was observed with a steady rise in hepatitis c virus (hcv) related hcc cases. hcv-3a, which is the most prevalent genotype, is also most frequent in hcv related hcc. there was an increase in the proportion of non-b non-...

BACKGROUND CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in aneuploidy which is a hallmark of most solid cancers, such as hepatocellular carcinoma (HCC). We investigate the expression of CENP-E in human hepatocellular carcinoma,. and ana...

Insulin-like growth factor binding protein-2 (IGFBP-2) can modulate proliferation and growth of tumor cells via specific binding onto insulin-like growth factor (IGF). Studies have shown that correlation between IGFBP-2 and hepatocyte carcinoma. Resveratrol has been demonstrated to modulate proliferation of hepatocyte carcinoma cells. As one homologous derivative of resveratrol, pterostilbene a...

Hepatocellular carcinoma (HCC) is a highly metastatic primary liver cancer generating molecular alterations that end up escaping the apoptotic machinery and conferring multidrug resistance. Targeted medicines with increased selective cytotoxicity minimal drug resistance are essential for treatment of HCC. In this study, self-assembled polycationic (PC) amphiphilic β-cyclodextrin (βCDC6) nanopar...

background hepatocellular carcinoma (hcc) is the fifth most common fatal cancer and an important healthcare problem worldwide. there are many studies describing the prognostic and predictive effects of epidermal growth factor receptor 2 (c-erb-b2) and epidermal growth factor receptor 1 (egfr), transmembrane tyrosine kinases that influence cell growth and proliferation in many tumors. objectives...

UNLABELLED miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. Although miR-302b has been suggested to function as a tumor repressor in other cancers, its role in hepatocellular carcinoma is unknown. This study investigated the expression and functional role of miR-302b in human hepatocellular carcinoma. The expression level of miR-302b is dramatically decrea...

miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. Although miR-302b has been suggested to function as a tumor repressor in other cancers, its role in hepatocellular carcinoma is unknown. This study investigated the expression and functional role of miR-302b in human hepatocellular carcinoma. The expression level of miR-302b is dramatically decreased in clin...