Hepatocellular carcinoma (HCC) is a highly metastatic primary liver cancer generating molecular alterations that end up escaping the apoptotic machinery and conferring multidrug resistance. Targeted medicines with increased selective cytotoxicity minimal drug resistance are essential for treatment of HCC. In this study, self-assembled polycationic (PC) amphiphilic β-cyclodextrin (βCDC6) nanopar...

Hepatocellular carcinoma (HCC) is a malignant tumor of the liver. Heat shock proteins play their part in response to cellular stress. They are overexpressed many forms cancers where they shield cells from stressful environment thus contributing poor prognosis and treatment resistance. HSP 27, heat protein mostly associated with Hepatitis induced hepatocellular cancer, inhibits apoptosis 70 alon...

Background and AimsThe growing knowledge of ferroptosis has suggested the regulatory role in hepatocellular carcinoma (HCC), but pertinent molecular mechanisms remain unclear. Herein, this study investigated mechanistic basis ferroptosis-related genes (ferrGenes) growth HCC.

Abstract: Background  and  Aims:  Huh-7  is  a  cell  line  that  was  derived  from  a  liver  tumor  of  a  Japanese  man.  Hepatocellular  carcinoma  (HCC)  is  considered  as  a  primary  liver  cancer.  Highly  resistant  tumor  to  treatment  which  causes  the  death  of  many  patients  annually.  Thus,  targeting  the  cancer  cells  by  using  a  new  method  could  be  effective  in...

objective(s): although low-dose radiotherapy (rt) that involves low collateral damage is more suitable for hepatocellular carcinoma (hcc) than traditional high-dose rt, but to achieve satisfactory therapeutic effect with low-dose rt, it is necessary to sensitize hcc cells to irradiation. this study was aimed to determine whether radiosensitivity of hcc cells can be enhanced using mir-26b by tar...

Tumor-associated macrophages (TAMs) are essential components of the immune cell stroma hepatocellular carcinoma. TAMs originate from monocytic myeloid-derived suppressor cells, peripheral blood monocytes, and kupffer cells. The recruitment monocytes to HCC tumor microenvironment is facilitated by various factors, leading their differentiation into with unique phenotypes. can directly activate o...

Aim: To evaluate the association of hepatitis with hepatocellular carcinoma. Hepatitis is known as inflammation liver. Methods: C and B may lead to HCC (hepatocellular carcinoma), such cause 50% responsible for 70 80 % cases HCC. Obesity, alcohol type 2 diabetes are also a predisposing factor malignant tumor, have low survival rate due reoccurrence. Results: Eighty two patients were selected Th...

Hepatocellular carcinoma (HCC) remains a major public health problem. MCM4, constitutive member of the minichromosomal maintenance protein family, has been reported to play vital role in cancer malignancy behavior. However, function MCM4 HCC largely unknown. The present study explored specific HCC. data from datasets including TCGA and GTEx showed that was overexpressed significantly associated...

Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are among the most common cancers across the world. Therefore, identifying the potential molecular mechanisms that promote HCC and CRC progression and metastasis are urgently needed. Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic enzyme that acetylates the high-order polyamines spermine and spermidine, thus decreasing th...

Abstract Background Hepatocellular carcinoma (HCC) can grow in a mosaic pattern, often combined with various non-hepatocellular cells. However, HCC neuroendocrine (NEC) component is rarely reported, and its clinical features, origin, diagnosis, behavior have not been established. In the literature, mixed HCC–NEC tumors are categorized as either collision type or type, depending on their microsc...