OBJECTIVES To determine the overall incidence of isoniazid (INH) hepatotoxicity in a public health tuberculosis clinic over a 7-year period, and to determine if systematic, limited aspartate aminotransferase (AST) monitoring would be of benefit in detecting INH hepatotoxicity. METHODS Evaluation of INH hepatotoxicity in adults aged > or = 25 years from a database maintained from fall 1996 to ...

CONTEXT Significant hyperlipidemia causing lipemic serum in patients with poorly controlled diabetes is under-reported in children. The recognition of the severe hyperlipidemia is important for proper management and to prevent associated morbidities. Severe hyperlipidemia in patients with diabetic ketoacidosis should be considered. CASE REPORT In this case we report a 2-year-old girl with new...

asparaginase is one of the most important agents in the treatment of all. however, it has some side effects including dislipidemia, hyperglycemia, coagulopathy and hepatotoxicity. we studied its side ef-fects on our patients. the effects of l-asparaginase were assessed on 25 new all patients (case group) and 25 patients with known all who had completed their treatment before. sixty two percent ...

BACKGROUND Herbal and dietary supplements are commonly used throughout the World. There is a tendency for underreporting their ingestion by patients and the magnitude of their use is underrecognised by Physicians. Herbal hepatotoxicity is not uncommonly encountered, but the precise incidence and manifestations have not been well characterised. AIMS To review the epidemiology, presentation and...

saffron, the dried red-orange stigmas of crocus sativus l, has been known as a flavoring agent, food coloring and traditional herbal medicine. pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. these components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

Chemotherapy-associated hepatotoxicity in liver metastatic colorectal cancer is attracting more and more attention for clinicians. This hepatotoxicity heralds an increased risk of morbidity and mortality in patients with colorectal liver metastases, therefore it is important that clinicians have an adequate knowledge of the chemotherapy-associated hepatotoxicity.

Gynostemma pentaphyllum (GP) is widely used for the treatment of diseases such as hyperlipidemia, fatty liver and obesity in China, and atorvastatin is broadly used as an anti-hyperlipidemia drug. This research focuses on the plasma and liver metabolites in the following four groups of rats: control, a hyperlipidemia model, a hyperlipidemia model treated with GP and a hyperlipidemia model treat...

PURPOSE Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect. The exact mechanism of methimazole-induced hepatotoxicity is still far from clear and no protective agent has been developed for this toxicity. METHODS This study attempts to evaluate the hepatotoxici...

BACKGROUND Systemic antifungal medications can be lifesaving but can also have important toxicities. With a number of new antifungal drugs being introduced, there is a compelling need to define the toxicities associated with existing therapies. METHODS We identified cases of hepatotoxicity among patients who underwent bone marrow transplantation and selected matched control subjects from the ...

PURPOSE: Trabectedin (Yondelis, ET-743) is a novel anticancer drug with potent activity against various tumors. However, dose-limiting hepatotoxicity was observed during clinical trials. Because recent reports have suggested that cytochrome P450 3A (CYP3A), as well as the drug transporters ABCB1, ABCC2, and ABCC3 might protect against trabectedin-mediated hepatotoxicity, we investigated the ind...