Since the first 70 years of reporting cancer chemotherapy, malignant tumors have been second most common cause death in children and adults. Currently, commonly used anti-cancer methods include surgery, radiotherapy, immunotherapy. Although these treatment could alleviate cancer, they lead to different forms side effects no particularly significant effect on prolonging patients’ life span. Glyc...

Mycotoxins are products of the secondary metabolism fungi, which can be present in food as contaminants. According to Food and Agriculture Organization (FAO), these substances, making them relevant global health, contaminate approximately 25% all worldwide. The occurrence exposure mycotoxins is more common developing countries, where their effects harmful health due high rate malnutrition place...

A study was undertaken to investigate the effect of cholestin on the toxicity of vitamin A in male wistar rats. The rats were divided into six groups and fed different diets with or without supplement of 1% cholestin and 25,000-50,000 (IU) vitamin A for 2 months. Hence, the symptoms of vitamin A toxicity in rats included loss of body weight, hepatotoxicity and nephrotoxicity. However, these tox...

BACKGROUND One of the main therapeutic limitations of cisplatin (CP) is nephrotoxicity which is time-dependent. OBJECTIVES The purpose of this study was to determine the optimal timing for initiation of CP toxicity. MATERIALS AND METHODS Sixty male and female Wistar rats were randomly divided into five groups. All the animals in groups 2-5 received single dose of CP (10 mg/kg; i.p.), and we...

To the Editor: The anti-tuberculosis (TB) therapy can cause various drug adverse effects including hepatotoxicity, nephrotoxicity and skin rash.[1,2] There are some case reports about interstitial lung disease (ILD) such as pneumonitis caused by isoniazid (INH), rifampin (RFP), ethambutol (EMB).[3,4] The causative drug was discontinued permanently or re-administrated after desensitization thera...

Herbal medications are being progressively utilized all over the world. Nevertheless, herbal remedies are not without hazards and several cases of adverse reactions have been described. Tribulus terrestris is traditionally used because of its aphrodisiac and antiurolithiatic activities with almost complete inhibition of stone formation. We report a case of T. terrestris-induced hepatotoxicity, ...

Herbal medicines are being increasingly used for treatment of variety of disorders. Herbal medicines are generally thought to lack severe side effects. Despite of the general belief, herbal medicines are known to cause serious side effects and toxicities. On the other hand, physicians’ knowledge of herbal medicines and their potential toxicities are generally limited. Neurotoxicity, cardiac tox...

Seven patients on dialysis with renal failure received transplants from mismatched cadaver donors and were treated with cyclosporin A (CyA), initially as the sole immunosuppressive agent. CyA was effective in inhibiting rejection but there was clear evidence of both nephrotoxicity and hepatotoxicity. A cyclophosphamide analogue was added to the CyA treatment in six of the patients. Five patient...