A central tenet underlying the use of botanical remedies is that herbs contain many active ingredients. Primary active ingredients may be enhanced by secondary compounds, which act in beneficial synergy. Other herbal constituents may mitigate the side effects of dominant active ingredients. We reviewed the literature concerning medical cannabis and its primary active ingredient, ∆9-tetrahydroca...

Recently, synthetic cannabinoids originally designed for testing in the laboratory only have found use recreationally in designer herbal blends, originally called "Spice". The myriad of compounds found are for the most part potent full agonists of the cannabinoid receptor 1, producing effects similar to tetrahydrocannabinol (THC) and marijuana. Drug discrimination of these compounds offers a sp...

The growing market of herbal remedies worldwide could pose severe problems to consumers’ health due to the possible presence of potentially harmful, undeclared synthetic substances or analogues of prescription drugs. The present work shows a simple but effective approach to unequivocally identify synthetic anorectic compounds in allegedly ‘natural’ herbal extracts, by exploiting Q-TOF LC/MS tec...

Undeclared synthetic substances or analogues of prescription drugs in herbal remedies can cause potential harm. The present work shows a simple but effective approach to unequivocally identify synthetic anorectic compounds in what is considered ‘natural’ herbal extracts, by exploiting Q-TOF LC/MS technology, with the help of the Agilent’s Forensic Accurate Mass Li-brary (Forensic PCDL AM), Agil...

Undeclared synthetic substances or analogues of prescription drugs in herbal remedies can cause potential harm. The present work shows a simple but effective approach to unequivocally identify synthetic anorectic compounds in what is considered ‘natural’ herbal extracts, by exploiting Q-TOF LC/MS technology, with the help of the Agilent’s Forensic Accurate Mass Li-brary (Forensic PCDL AM), Agil...

herbal medicines include a range of pharmacologically active compounds: in some cases it is not well understood which ingredients are important for a therapeutic effect. the supporters of herbal medicine believe that isolated ingredients in the majority of cases have weaker clinical effects than whole plant extract, a claim that would obviously require proof in each case. generalizations about ...

Purpose. Primary dysmenorrhea (PD) is a common gynecological complaint among adolescent girls and women of reproductive age. This study aims to review the findings of published articles on the in vitro and in vivo efficacy of herbal medicines for PD. Methods. In vitro and in vivo studies of herbal compounds, individual herbal extracts, or herbal formula decoctions published from their inception...

Jodeungsan (JDS) is a traditional herbal formula that comprises seven medicinal herbs and is broadly utilized to treat hypertension, dementia, and headache. However, the effects of JDS and its herbal components on neurodegenerative diseases have not been reported. We examined the inhibitory effects of JDS and its seven components on neuronal cell death and inflammation using HT22 hippocampal ce...

Herbal preparations are complex mixtures of natural products, many of which are able to reach the distal gut due to low oral bioavailability. There, they can influence the microbial communities, and can be metabolized into potentially absorbable bioactive compounds by the intestinal bacteria. This aspect has often been disregarded when searching for the active principles of medicinal plants and...