The correlation between hereditary thrombophilia and fetal loss is supported by several observations. In murine models, the protein C system has been shown to be essential for the maintenance of pregnancy, as it indirectly acts as a growth factor for trophoblast cells and protects them from apoptosis. In humans, it has been shown that the placenta replaces the yolk sac as an essential source of...

deficiency' and reflects the importance of this serine protease inhibitor for the anticoagulant activity of heparin. Our experience shows the importance of screening for an underlying disorder in the young with thrombosis and strongly suggests that prophylactic measures aimed at preventing thrombosis should be considered in acutely ill subjects with infection and familial thrombophilia. 1 Rosen...

Cerebral vein thrombosis (CVT) is uncommon disease and known risk factors of CVT are hereditary thrombophilia, pregnancy, puerperium, and use of oral contraceptives. However, 25% of all cases are considered to be idiopathic. Thyrotoxicosis may be a predisposing factor of CVT due to a hypercoagulable state. Possible associations between thyrotoxicosis and CVT have been described in several case ...

PURPOSE The association of retinal vein occlusion and hereditary thrombophilia abnormalities is not established, with controversial results in the literature. This study investigates the association between retinal vein occlusion and three thrombophilic mutations: factor V 1691A (factor V Leiden), prothrombin 20210A (PT 20210A) and homozygous methylenetetrahydrofolate reductase 677T (MTHFR 677T...

Background: Beta-2 glycoprotein I antibodies (B2-GPI Ab) are significant markers of thrombosis in otoimmune diseases. No literature has been found in Bcr Abl (-) MPNs to exclude the risk of hereditary thrombophilia and to investigate the association of B2-GPI Ab levels with thrombosis. This study aimed to investigate the relation between levels of B2-GPI Ab and thrombosis in BcrAbl (-) MPN with...

BACKGROUND The association among hereditary thrombophilia, recurrent pregnancy loss (RPL) and obstetric complications is yet uncertain. The objective of the study was to assess the prognostic value of the factor V Leiden (FVL) and prothrombin (PT) mutations for the subsequent chance of live birth for women with RPL. METHODS Pregnancy outcome was recorded in a retrospective cohort of 363 women...

OBJECTIVE Renal infarction is rare and has variable clinical presentations causing diagnostic difficulties. Although most renal infarctions are caused by an obvious thromboembolic factor some are only explained by hereditary or acquired thrombophilia. The authors present a case of segmental renal infarction associated with factor V Leiden. METHODS/ RESULTS: A 48-year-old man presented with righ...