Hesperidin is a flavonone glycoside found in sweet orange and is effectively used in treatment for pain and disease. Although it plays a big role in the pharmaceutical area, hesperidin has a poor water soluble property. β-cyclodextrin (β-CD), a macrocyclic host with hydrophobic cavity and hydrophilic outer surface is a common pharmaceutical application to enhance the solubility, stability, safe...

Superoxide dismutase type 1 (SOD1) mutations cause protein aggregation and decrease protein stability, which are linked to amyotrophic lateral sclerosis (ALS) disease. This research utilizes the world's largest traditional Chinese medicine (TCM) database to search novel inhibitors of mutant SOD1, and molecular dynamics (MD) simulations were used to analyze the stability of protein that interact...

Background: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (contr...

Hesperidin is abundantly present as a flavanone glycoside in citrus fruits. The peels, seeds, pulp, and cell membrane residues contain high amount of hesperidin. It has received scientific momentum lately it offers several health benefits upon consumption, possesses antioxidant, anti-hypocholesteric, antitumor, anticancer, antimicrobial, antibacterial, anti-inflammatory, anti-diabetic propertie...

OBJECTIVE Parkinson's disease (PD) may be caused by the interaction of a number of factors, including genetics, toxins, oxidative stress, mitochondrial abnormalities, and aging. Studies have shown that consumption of an antioxidant-rich diet may reduce the incidence of neurodegenerative diseases. The aim of this study was to evaluate the role of the flavonoid hesperidin in an animal model of PD...

Diosmin and hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. Diosmin for pharmaceutical use is obtained mainly semi-synthetically from hesperidin. Hesperidin often accompanies diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous a...

This study was conducted to investigate the supplemental effects of purified bioflavonoids (genistein and hesperidin), as potential alternatives to plant/herbs or synthetic antioxidants, individually and in combination for fatty acid profile, lipid metabolites, and antioxidant status of broilers. Three hundred sixty 1-d-old broilers were divided into 6 treatment groups: control (basal diet), G5...

Free radicals play an important role in stomach ulcer formation. The present investigation validates the anti ulcer activity of hesperidin, isolated from Citrus sinensis (L.) Osbeck, Rutaceae, through the assessment of its antioxidant potential over stomach mucosal tissue by histological examination. Hesperidin was isolated from the dried peel of C. sinensis, and authenticated by TLC, IR and HP...

AIM Lycopene, a carotenoid and hesperidin, a flavonoid are naturally occurring in vegetables and fruits. Synergistic effect of a combination of carotenoid and flavonoid has been reported due to its antioxidant activity. Therefore, the present study was aimed to evaluate the protective effect of this combination on pylorus ligation induced ulcers in rats. MATERIALS AND METHODS Thirty Wistar al...

This paper reviewed the polyphenolic compound, hesperidin, found mostly in citrus fruit peels and examined its use animal reproduction. Hesperidin, as a bioflavonoid flavanone glycoside, has wide range of biological therapeutic benefits. Its application enhancement reproductive indices animals is limited due to low water solubility, poor absorption bioavailability. Synthetic variants hesperidin...