MOTIVATION Next-generation sequencing technology is increasingly being used for clinical diagnostic tests. Clinical samples are often genomically heterogeneous due to low sample purity or the presence of genetic subpopulations. Therefore, a variant calling algorithm for calling low-frequency polymorphisms in heterogeneous samples is needed. RESULTS We present a novel variant calling algorithm...

background: inversion of the uterus is very uncommon. patients may present with pelvic pain, vaginal discharge, or hemodynamic shock. case: we report a case of 35 years old women (virgin) who was admitted with profuse vaginal bleeding and cramps of uterus. in the vaginal examination at litothomy position a mass of 58 cm in size was protruded from the vagina. at first myomectomy was performed a...

NUCLEAR R1BONUCLEOPROTEIN PA TICLES .................................................................... 461 Evidence for, and lsolation of, hnRNP Particles ....................................................... 461 General Structural Features of hnRNP articles ...................................................... 467 Proteins of hnRNP Particles ..................................................

TLR signaling is associated with the transcription of various proinflammatory cytokines, including TNF-α, IL-6, and IL-1β. After transcription, the mRNA of these proinflammatory cytokines needs to be tightly controlled at the posttranscriptional level to achieve an optimal expression. However, the precise mechanism of posttranscriptional regulation is not fully understood. In the current study,...

Consider inference with a small number of potentially heterogeneous clusters. Suppose estimating the model on each cluster yields q asymptotically unbiased, independent Gaussian estimators with potentially heterogeneous variances. Following Ibragimov and Müller (2010), one can then conduct asymptotically valid inference with a standard t-test based on the q cluster estimators, since at conventi...

Presently, conditions ensuring the validity of bootstrap methods for the sample mean of (possibly heterogeneous) near epoch dependent (NED) functions of mixing processes are unknown. Here we establish the validity of the bootstrap in this context, extending the applicability of bootstrap methods to a class of processes broadly relevant for applications in economics and Þnance. Our results apply...

L-moment ratio diagrams are increasingly being used in the literature for selecting a probability distribution function for regional frequency analysis. Two graphical methods are often used in the distribution selection process, the sample average and a line of best-fit through the sample L-moment ratios. Examples of homogeneous and heterogeneous regional samples are simulated to illustrate the...

poly (n-bromosuccinimide) (pnbs) as a mild, efficient, non-acidic, polymeric and heterogeneous catalyst was applied for simple conversion of epoxides into thiiranes by treatment with kscn or (nh2)2cs at room temperature. aliphatic and aromatic epoxides converted into their corresponding thiiranes under mild conditions. all reactions proceeded in short reaction times and afforded the correspondi...