Hub location problems are strategic network planning problems. They formalise the challenge of mutually exchanging shipments between a large set of depots. The aim is to choose a set of hubs (out of a given set of possible hubs) and connect every depot to a hub so that the total transport costs for exchanging shipments between the depots are minimised. In classical hub location problems, the un...

Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC) are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works propo...

Design of network, through which data, packages or even people can be transported, is an important issue for achieving a desired level of service quality at an acceptable cost. For this purpose, it is possible to design a network comprised of nodes that are connected to each other with dedicated lines. However, this kind of solution will not be cost effective. In order to decrease the total tra...

We address the problem of designing two-level networks protected against single edge failures. A set of nodes must be partitioned into terminals and hubs, hubs must be connected through a backbone network, and terminals must be assigned to hubs and connected to them through access networks, being the objective to minimize the total cost. We consider two survivable structures, two-edge connected...

conclusions our results revealed the possible crucial genes and mirnas involved in the initiation and progression of hcc cells infected with hcv. results based on the topological analysis of mirna-hubgene network, we identified the key hub mirnas. in order to identify the most important common sub-network, we aligned two ppi networks using netal tool. the c-jun gene was identified as the most i...

This study investigates the contributions of network topology features to the dynamic behavior of hierarchically organized excitable networks. Representatives of different types of hierarchical networks as well as two biological neural networks are explored with a three-state model of node activation for systematically varying levels of random background network stimulation. The results demonst...

BACKGROUND Parkinson's Disease (PD) is a progressive neurologic disorder that affects movement and balance. Recent studies have revealed the importance of microRNA (miR) in PD. However, the detailed role of miR and its regulation by Transcription Factor (TF) remain unexplored. In this work for the first time we have studied TF-miR-mRNA regulatory network as well as miR co-expression network in ...