نتایج جستجو برای: hif
تعداد نتایج: 10220 فیلتر نتایج به سال:
The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β-subunit. While HIF-1 and HIF-2 function as master regulators of the transcriptional response to hypoxia, much less is known about HIF-3. The HIF-3α gene gives rise to multiple HIF-3α variants due to the utilization of ...
HIF-1 (hypoxia-inducible factor-1), a heterodimeric transcription factor comprising HIF-1alpha and HIF-1beta subunits, serves as a key regulator of metabolic adaptation to hypoxia. HIF-1 activity largely increases during hypoxia by attenuating pVHL (von Hippel-Lindau protein)-dependent ubiquitination and subsequent 26 S-proteasomal degradation of HIF-1alpha. Besides HIF-1, the transcription fac...
Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α). Materials and Methods: We constructed rat models with myocardial I/R injury and H9C2 cell models with hypoxia/reoxygenation (H/R) damage. Anti-miR-155 and...
Background and Aim: One of the most common metabolic diseases is diabetes with hyperglycemic properties and endogenous insulin dysfunction. This study aimed to evaluate the effect of 10 weeks HIIT on HIF-1α gene expression in heart tissue of rats with type 2 diabetes. Methods: In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic,...
The expressions of hypoxia-inducible genes are upregulated by hypoxia-inducible factor 1 (HIF-1), which is a heterodimer of HIF-1alpha and HIF-1beta/ARNT (aryl hydrocarbon receptor nuclear transporter). Under hypoxic conditions, HIF-1alpha becomes stabilized and both HIF-1alpha and ARNT are translocated into the nucleus and codimerized, binding to the HIF-1 consensus sequence and transactivatin...
Recent efforts have been aimed at targeting the hypoxia inducible factor (HIF)-mediated hypoxia-induced gene pathway for renal cell carcinomas (RCC) therapy. Among the various genes induced by HIF, vascular endothelial growth factor (VEGF) is one of the critical mediators in angiogenesis, tumor growth and metastasis. To date, however, limited information is available on the functional differenc...
فرایند هیپوکسی یا عدم تعادل بین میزان اکسیژن در دسترس با اکسیژن مصرفی، به طور معمول در سرطان و بیماری های ایسکمی قلبی- عروقی رخ می دهد. در سلول های توموری به منظور سازگاری با این شرایط بیان ژن هایی که بیشتر در آنژیوژنز، چرخه ی سلول و متابولیسم آن نقش دارند توسط فاکتور القا شونده با هیپوکسی- 1 (hif-1) تنظیم و کنترل می شود. به تازگی توصیف ویژگی های مولکولی مسیرهای آنژیوژنیکی، این فاکتور را به عنو...
چکیده سابقه و هدف سلولهای بنیادی مزانشیمی، یک منبع سلولی ایدهآل برای پیوند میباشند. اما استرسهای مختلف در طول تکثیر آزمایشگاهی منجر به کاهش بقای سلولی آنها پس از پیوند میشود. بنابراین به کارگیری راهکارهای عملی جهت افزایش میزان بقای آنها در ریز محیط سرشار از استرس بسیار ضروری است. هدف این مطالعه، بررسی اثر سکرتوم ترشحی سلولهای بنیادی مزانشیمی دستورزی شده با دو ژن Nrf2 و HIF-1&alpha ب...
Hypoxia-inducible factor-1α (HIF-1α) is known as a transactivator for VEGF gene promoter. It can be induced by hypoxia. However, no study has been done so far to dissect HIF-1α-mediated effects from hypoxia or VEGF-mediated effects. By using a HIF-1α knockout (HIF-1α KO) cell system in mouse embryonic fibroblast (MEF) cells, this study analyzes cell migration and HIF-1α, hypoxia and VEGF activa...
Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism for its action is that it prevents the proteasomal degradation of proapoptotic proteins, leading to enhanced apoptosis. Although the α subunit of hypoxia-inducible factor (HIF)-1 is not degraded with bortezomib treatment, the...
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