Microbubbles (MBs) are considered as an important enhancer for high intensity focused ultrasound (HIFU) treatment of benign or malignant tumors. Recently, different sizes of gas-filled bubbles have been investigated to improve the therapeutic efficiency of HIFU thermal ablation and reduce side effects associated with ultrasound power and irradiation time. However, nanobubbles (NBs) as an ultras...

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU mo...

BACKGROUND Thermal and mechanical high intensity focused ultrasound (HIFU) ablation techniques are in development for non-invasive treatment of cancer. However, knowledge of in vivo histopathologic and immunologic reactions after HIFU ablation is still limited. This study aims to create a setup for evaluation of different HIFU ablation methods in mouse tumors using high-field magnetic resonance...

The requirements for beamforming in high intensity focused ultrasound (HIFU) for tissue destruction are substantially different than those for diagnostic imaging. High numerical aperture and CW efficiency are desirable for tissue destruction, while depth of focus and broadband sensitivity are key to good imaging. When the same transducer must be used for ablation and imaging some compromises mu...

The potential of high‐intensity focused ultrasound (HIFU) will not be realized unless the effects of overlaying tissues are understood in such a way that allows for estimation of HIFU dose distribution at a target tissue. We employ computational models to examine the impact of phase aberration on tissue ablation. Thompson and Roberts have recently studied the effects of phase aberration on ultr...

Application of high-intensity focused ultrasound (HIFU) in therapeutic medicine has started in the 1950s for the treatment of Parkinson’s disease. With the development of medical diagnosis, such as ultrasound imaging and magnetic resonance imaging (MRI), automatic control, imaging processing and electrical technology, extracorporeal and intrarectal HIFU systems have been developed for clinical ...

INTRODUCTION Active surveillance for low risk prostate cancer has become an acceptable management strategy. However, a percentage of these patients in active surveillance move on to active treatment. Our aim was to examine urinary incontinence (UI) rates in men who move on to treatment from active surveillance and compare it to quoted rates in the literature. We examined the question that a ...

The thermal effect of high intensity focused ultrasound (HIFU) has been clinically exploited over a decade, while the mechanical HIFU is still largely confined to laboratory investigations. This is in part due to the lack of adequate imaging techniques to better understand the in-vivo pathological and immunological effects caused by the mechanical treatment. In this work, we explore the use of ...

Background/introduction Obstruction by the thoracic cage of the high intensity focused ultrasound (HIFU) beam is one of the major challenges in the ablation of abdominal lesions. Several beam shaping methods have been proposed to reduce exposure of the ribs to acoustic energy and to recover focal point intensity. The feasibility of HIFU ablation of a clinically relevant volume applying beam sha...