Immunization of rabbits from a closed colony with streptococcal Group A-variant vaccines identified about two-thirds of them as low and heterogeneous responders. One-third of the rabbits showed a restriction of the response independent from the magnitude. Selective breeding from one monoclonal high-responder male and two restricted high-responder female rabbits succeeded in segregation of high-...

The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...

A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...

Biologic TNFα inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many patients either do not respond or relapse after initially responding to these agents. This study was carried out to identify biomarkers that can distinguish responder from non-responder patients before the initiation of treatment. The level of...

We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) in basophils. We have also demonstrated that HRF/TCTP primes basophils to release mediators. The purpose of this study was to begin characterization of...

in vitro lymphocyte responses of high responder (hr) and low responder (lr) guinea pigs from pe-ripheral blood lymphocytes (pbl) to parasite antigens soluble protein third stage larvae (spl3) and soluble protein adult stage ( spa), non-parasite antigen ovalbumin (ova) were examined. there was substantial differences between hr and lr guinea pigs in the rate of acquisition of responsiveness to t...

BACKGROUND There have been few clinical studies on 10 mg atorvastatin as a starting dosage for treatment of hypercholesterolemia in type 2 diabetes mellitus (T2DM) patients. This retrospective study aims to evaluate the efficacy of 10 mg dosage of atorvastatin in clinical setting. METHODS One hundred five enrolled patients with high levels of low density lipoprotein cholesterol (LDL-C, > 100 ...