background: gabaergic interneurons in the hippocampal ca1 area are mutually communicated by gap junctions (gjs) composed of connexin36 (cx36). we examined the role of cx36 in ca1 in manifestation of kindled seizures and hippocampal kindling in rats. methods: quinine, as the specific blocker of cx36, was injected into ca1, and kindled seizures severity was examined 10 min afterward. moreover, qu...

Abstract Hippocampal changes in epilepsy may manifest as hippocampal atrophy/sclerosis. A recent human study suggests that the demonstration of volume loss is more reliable using quantitative evaluation methods. The aim present was to obtain volumetric data both epileptic and healthy dogs, compare volumes groups, subjective assessment. Volumetric measurements hippocampi, lateral ventricles hemi...

introduction: the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is to assess the effects of hippocampal 5-ht4 receptor on memory acquisition deficit induced by harmaline.  methods: harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs...

background: an important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. coriandrum sativum has been shown that have antioxidant effects. central nervous system depressant effects of c. sativum have also been reported. in this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures in...

introduction: antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. methods: electr...

morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. the present study intended to investigate whether administration of morphine ...

Despite the use of fluoxetine as a first-line therapy, some patients do not show good therapeutic effect. Effective antidepressant therapy will reverse low serotonin and BDNF levels found in depression. Mozart K. 448 was reported to yield effect for Based on findings, combination depression is very rare. Therefore, this study aimed determine combined hippocampal an animal model under CUMS condi...