indacrinone is a loop diuretic which also has uricosuric, kaliuretic, saliuretic and natriuretic effects. since it has been reported that this drug has several actions in different organs, we decided to evaluate its mechanism of action on the rat jejunum smooth muscle. after preparation of the tissues, different concentrations of indacrinone were applied. doses of 8.2×10^-6 m, 2.7×10^-5 m, 8.2×...

the role of endogenous histamine and h1, h2 and h3 central receptors on food intake in broiler chickenswas investigated. for this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (icv) injection of thioperamide, an h3 receptor antagonist, and r-α-methylhistamine, an h3 receptor agonist and subsequently the effects of brain histaminergic...

In the present study we investigated the participation of central H1 and H2 histaminergic receptors in water intake induced by hyperosmolarity (evoked by intragastric salt load), by hypovolemia (promoted by the subcutaneous administration of polyethyleneglycol) and by the pharmacological stimulation of central cholinergic pathways by the muscarinic agonist carbachol in male Wistar rats. The dat...

Stress induced analgesia (SIA) is well known, but the reverse phenomenon, hyperalgesia is poorly documented. This study investigated the role of the histaminergic system in restraint stress hyperalgesia in rats, using thermal stimulation method (hot plate and tail flick tests). Paw licking and tail withdrawal latencies were taken before and after restraint for about one hour. Significant decrea...

H1 and H2 histamine receptor antagonists, although developed many decades ago, are still effective for the treatment of allergic and gastric acid-related conditions. This article focuses on novel aspects of the pharmacology and molecular mechanisms of histamine receptors that should be contemplated for optimizing current therapies, repositioning histaminergic ligands for new therapeutic uses, o...

Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the ...