background: research says that diabetes may develop in over 10% of non-diabetic pregnant women. diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. in most cases, diabetic symptoms disappear after delivery. hla-g has an important role bo...

BACKGROUND HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to inhibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace thei...

BACKGROUND The physiological functions of the classical HLA (human leukocyte antigen) molecules, HLA-A, HLA-B and HLA-C, are to present peptides to T cells and to inhibit the activity of natural killer cells. In contrast, the functions of nonclassical HLA-molecules, such as HLA-E, HLA-F and HLA-G, remain to be established. The expression of HLA-G is largely limited to the placental trophoblast,...

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

The non-classical HLA Class I molecule HLA-G was discovered at the fetal–maternal interface, but over the past few years, the tissue distribution of HLA-G in normal tissues has been found to be broader than originally reported: (i) HLA-G molecules have been detected from oocyte to blastocyst stage, then in invasive trophoblast, amniotic cells and fluid, endothelial cells from the chorionic vill...