Mature B-cell non-Hodgkin lymphoma is the most common subtype of non-Hodgkin lymphoma in childhood and adolescence. B-cell non-Hodgkin lymphomas are further classified into histological subtypes, with Burkitt lymphoma and Diffuse large B-cell lymphoma being the most common subgroups in pediatric patients. Translocations involving the MYC oncogene are known as relevant but not sufficient for Bur...

Gynecological lymphoma is one of the rarest tumors of the female organs that need to be kept in mind in a suspected patient due to its different management protocol. Even though the reported cases of ovarian lymphoma are not limited; our knowledge about diagnosis and treatment of primary cervical lymphoma is restricted. There is a rising number of suggested imaging and pathological criteria tha...

conclusions the association between viral hepatitis and nhl in the area of interest might provide some degree of explanation to this finding. our data confirm that due to epidemic infection of hcv in the area of naples, a high mortality for nhl persists, moreover the adoption of standard therapeutic protocols administered in full accordance with an evidence-based approach and current guidelines...

the most frequently studied association between a hepatitis virus and non hodgkin lymphoma (nhl) has been with hepatitis c virus (hcv). association with hepatitis b virus (hbv) is less studied. in this regard mixed cryoglobulinemia (mc) is more commonly associated with hcv than hbv. still rarer is cryofibrinogenemia in these patients.   lack of symptoms in addition its rarity delays the diagnos...

abstract background involvement of lacrimal apparatus by non hodgkin lymphoma as a first manifestation is extremely rare and only three cases have been reported in children. the purpose of this report is to determine the clinical characteristic of patient with primary involvement of lacrimal apparatus with lymphoma. case presentation a 7-year-old girl with history of tearing, gradually progress...

Brentuximab vedotin (BV) is an antibody-drug conjugate that specifically delivers the potent cytotoxic drug monomethyl auristatin E (MMAE) to CD30-positive cells. BV is FDA approved for treatment of relapsed/refractory Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL); however, many patients do not achieve complete remission and develop BV-resistant disease. We selected for BV-resistan...

Brentuximab vedotin (BV) is an antibody–drug conjugate that specifically delivers the potent cytotoxic drug monomethyl auristatin E (MMAE) to CD30-positive cells. BV is FDA approved for treatment of relapsed/refractory Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL); however, many patients do not achieve complete remission and develop BV-resistant disease. We selected for BV-resistan...

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...

Richter's transformation of chronic lymphocytic leukaemia (CLL) to high-grade B-cell Non-Hodgkin lymphoma occurs in < 5% of CLL cases. Transformation of CLL to Hodgkin Lymphoma is a much rarer event and here we describe a patient who developed Richter's transformation into a Hodgkin Lymphoma presenting as rapidly progressive hepatosplenomegaly.