Abstract The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T 3 ) and its cognate nuclear receptors. Thyroid is a pleio-tropic regulator growth, differentiation, tissue homeostasis in higher organisms. major site action predominantly cell nucleus. specific binding sites nuclei have opened new era field receptors (TRs) discovery. ...

background: to attain whether the effects of low and high doses of estrogen progesterone luteinizing hormone (lh) and follicle stimulating hormone (fsh) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (cox-1) activity. materials and methods: acute and chronic administration of estrogen (1 and 5 mg/ kg) prog...

Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural...

Hormone binding to receptors on the cell surface triggers a sequence of events (receptor activation and signal generation) leading to activation of effectors in the cytoplasm. Receptor activation and signal generation are difficult to study as both are intimately associated with hormone binding. The lutropin-choriogonadotropin (LH/CG) receptor offers a unique model to differentiate and examine ...

Estrogen is an important hormone for health in both genders. It indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular and neural functions. The main way that estrogen acts the cells through receptors (ERs). presence of specific required have its characteristic ubiquitous action almost all tissues. receptor alpha (ER?) beta (ER?) are major isoforms highly humans en...

Triple-negative breast cancer (TNBC) is considered one of the most aggressive forms with poor survival rates compared to other subtypes. TNBC characterized by absence estrogen receptor alpha, progesterone receptor, and human epidermal growth factor 2, limiting those viable treatment options available patients Furthermore, due particularly high heterogeneity TNBC, conventional treatments such as...

The advent of ultramicroscale purification and analysis technology, along with gene manipulation techniques, has greatly accelerated progress in molecular cell biology. (We used to call this "Biochemistry.") Nowhere is the rate of progress more impressively evident than in the field of hormone receptor study, where the enthusiastic research of numerous investigators is rapidly clarifying struct...

3 oxygen therapy have recently been published! Subsequent information may equip physicians with improved insight as to when low-flow oxygen therapy should be instituted earlier in the course of treatment and which patients may benefit most. The economic aspects of continuous low flow oxygen therapy demand careful investigation beibre further recommendations are made. Philip G. Boysen, M.D., F.C...

Background To attain whether the effects of low and high doses of estrogen progesterone luteinizing hormone (LH) and follicle stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (COX-1) activity. MaterialsAndMethods Acute and chronic administration of estrogen (1 and 5 mg/ kg) progeste...