It has been demonstrated that the chromosomal translocation t(7;11)(p15;p15) in patients with human acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML) invariably involves fusion of the nucleoporin gene, NUP98, on chromosome 11 and the class 1 HOX gene, HOXA9, on chromosome 7, and that the fusion gene NUP98-HOXA9 is an important gene in myeloid leukemogenesis. Here are repor...

Hox genes are well known for their key contribution to the establishment of the body architecture. This function relies on both local and long-range cis-regulatory elements that generate nested expression patterns of the various Hox genes along the anterior–posterior axis of the developing embryo. Interestingly, analyses of expression patterns in different species suggested that modulation of t...

Parameter optimization coupled with model selection is a convenient approach to infer gene regulatory networks from experimental gene expression data, but so far it has been limited to single cells or static tissues where growth is not significant. Here, we present a computational study in which we determine an optimal gene regulatory network from the spatiotemporal dynamics of gene expression ...

Hox genes are well known for their key contribution to the establishment of the body architecture. This function relies on both local and long-range cis-regulatory elements that generate nested expression patterns of the various Hox genes along the anterior–posterior axis of the developing embryo. Interestingly, analyses of expression patterns in different species suggested that modulation of t...

An enduring problem in biology is explaining how novel functions of genes originated and those diverge between species. Despite detailed studies on the functional evolution a few proteins, molecular mechanisms by which protein have evolved are almost entirely unknown. Here, we show that polyalanine tract homeodomain transcription factor HoxA11 arose stem-lineage mammals as an autonomous repress...