In women, there is evidence that a single nucleotide polymorphism (SNP) in the histidine-rich glycoprotein (HRG) named HRG C633T is relevant for a number of fertility outcomes including recurrent miscarriage, ovarian response and pregnancy outcome after IVF. This case-control study was designed to investigate whether the HRG C633T SNP is important for male infertility and pregnancy rate followi...

Studies of human cerebral cortex development are limited by difficulties in accessing and manipulating human neural tissue at specific development stages. We have derived human radial glia (hRG), which are responsible for most cerebral cortex neurogenesis, from human pluripotent stem cells. These hRG display the hallmark morphological, cellular, and molecular features of radial glia in vitro. T...

for AACR annual meeting 2006 Heregulin β1 induces cyclin D1 and p21 expression and promotes breastcancer cell proliferation through ErbB receptor/Rac/Erk Chengfeng Yang, Ying Liu, Mark A. Lemmon, and Marcelo G. Kazanietz. Department of Pharmacology, University of Pennsylvania School of Medicine,Philadelphia, PA 19104-6160 The human ErbB receptor family comprises 4 tyrosine kinase recept...

Lindgren, K. E. 2016. The Histidine-rich Glycoprotein in Reproduction. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1244. 76 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9648-7. Infertility affects 15% of reproductive-aged couples. The milieu surrounding the growing embryo is of outmost importance, and should be optimised during in vitro ...

Binding of heregulin (HRG) to its receptor, ErbB3, results in a dimerization with ErbB2/neu and activation of their intrinsic tyrosine kinases, initiating a cascade of events resulting in the stimulation of acetylcholine receptor (AChR) genes in muscle. Here we have examined the signalling downstream of the HRG receptor. We show that phosphatidylinositol 3'-kinase (PI3K) and SHC bind to the HRG...

BACKGROUND Histidine-rich glycoprotein (HRG) has previously been shown to have an impact on implantation and fertility. The aim of this study was to investigate if there is an association between the HRG A1042G single nucleotide polymorphism (SNP) and recurrent miscarriage. METHODS The study was designed as a case-control study and the women were included at University Hospitals in Sweden. 18...

Histidine-rich glycoprotein (HRG) is a plasma protein consisting of 6 distinct functional domains and is an important regulator of key cardiovascular processes, including angiogenesis and coagulation. The protein is composed of 2 N-terminal domains (N1 and N2), 2 proline-rich regions (PRR1 and PRR2) that flank a histidine-rich region (HRR), and a C-terminal domain. To date, structural informati...

A novel design of force to rebalance control for a hemispherical resonator gyro (HRG) based on FPGA is demonstrated in this paper. The proposed design takes advantage of the automatic gain control loop and phase lock loop configuration in the drive mode while making full use of the quadrature control loop and rebalance control loop in controlling the oscillating dynamics in the sense mode. Firs...

We analyzed the propensity of the HER3 receptor and its extracellular domain (ECD) to undergo ligand-independent self-association. The HER3-ECD, purified from Drosophila S2 cells, binds the EGF-like domain of heregulin (hrg) with a K(d) of 1.9 nM as measured by surface plasmon resonance (SPR) studies. In a gel shift assay, the HER3-ECD self-associates into a uniform, slowly migrating species in...

Nordqvist, S. 2014. Biological Markers of Fertility. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1048. 74 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9085-0. Infertility affects 15 % of couples, which corresponds to 60 80 million worldwide. The microenvironments in which the oocyte, embryo and fetus mature are vital to the establishment...