therefore, the objective of this study is to test the feasibility of uv-ir transmission spectroscopy for the non-destructive assessment of the freshness of an individual egg as an alternative for traditional inspection methods. to obtain a considerable variation in freshness, groups consisting of 10 eggs were stored (30 7 oc and 25% 4 rh) for 30 days. data obtained from non-destructive spectral...

PURPOSE Patients with hemoglobin SC (Hb SC) and hemoglobin SB+ (Hb SB+) thalassemia suffer from frequent hospitalizations yet strong evidence of a clinical benefit of hydroxyurea (HU) in this population is lacking. Patients with recurrent hospitalizations for pain crisis are offered HU at our institution based on small cohort data and anecdotal benefit. This study identifies outcomes from a lar...

In sickle cell disease (SCD), hydroxyurea (HU) treatment decreases the number of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) by increasing fetal hemoglobin (HbF). Data are lacking regarding the frequency of HU dose modification or whether sub-therapeutic doses (<15 mg/kg/day) are beneficial. We reviewed the medical records of 140 patients from 2010 to 2014. The laboratory paramet...

Urotensin-II (U-II), the most potent vasoconstrictor that has recently been recognized as a new candidate in cardiovascular dysfunction, might exert vasoconstriction through, at least partially, potassium channels that are predominant in both endothelial and vascular smooth muscle cells (VSMCs). The present study was designed to evaluate the roles of potassium channels in vascular responses to ...

The Morey-Holton hindlimb unloading (HU) method is a widely accepted National Aeronautics and Space Administration (NASA) ground-based model for studying disuse-atrophy in rodents. Our study evaluated an alternant method to the gold-standard Morey-Holton HU tail-traction technique in mice. Fifty-four female mice (4-8 mo.) were HU for 14 days (n=34) or 28 days (n=20). Recovery from HU was assess...

Human (Hu) lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the plasma metabolism of cholesterol. To assess the effects of increased plasma levels of LCAT, four lines of transgenic mice were created expressing a Hu LCAT gene driven by either its natural or the mouse albumin enhancer promoter. Plasma LCAT activity increased from 1.2- to 1.6-fold higher than that found in control mo...

Hydroxyurea (HU) is a well tolerated ribonucleotide reductase inhibitor effective in HIV, sickle cell disease, and blood cancer therapy. Despite a positive initial response, however, most treated cancers eventually progress due to development of HU resistance. Although RNR properties influence HU resistance in cell lines, the mechanisms underlying cancer HU resistance in vivo remain unclear. To...

normal 0 false false false en-us x-none ar-sa aim: ct number (hu) and linear attenuation coefficient contain useful information which  can be determined during usual ct scanning for the prediction of breast cancerous cells existence based on hemoglobin concentration. methods: this study used breast phantom containing major and minor vessels with diameters of 10 and 5 mm, respectively. the major...

23 24 Some unidentified RNA molecules, together with the nucleoid protein HU, were 25 suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved 26 protein known for its role in binding to DNA and maintaining negative supercoils in the 27 latter. HU also binds to a few RNAs but the full spectrum of its binding targets in the cell 28 is not known. To understand any...