Abstract Due to their mulitpotency, Mesenchymal stem cells (MSCs), have the ability to proliferate and differentiate into multiple mesodermal tissues. The aim of this study was to isolate MSCs from human Umbilical Cord (hUCMSCs) to determine their osteogenic potential on nanofibrous scaffolds. To this end, Poly (L-lactic acid) (PLLA)/Nano hydroxyapatite (HA) composite nanofibrous scaffolds were...

abstract due to their mulitpotency, mesenchymal stem cells (mscs), have the ability to proliferate and differentiate into multiple mesodermal tissues. the aim of this study was to isolate mscs from human umbilical cord (hucmscs) to determine their osteogenic potential on nanofibrous scaffolds. to this end, poly (l-lactic acid) (plla)/nano hydroxyapatite (ha) composite nanofibrous scaffolds were...

Bone marrow-derived mesenchymal stem cells (BMSCs) are a major source for cell transplantation. The proliferative ability of BMSCs is an important determinant of the efficiency of transplant therapy. Sertoli cells are "nurse" cells for development of sperm cells. Our recent study showed that Sertoli cells promoted proliferation of human umbilical cord mesenchymal stem cells (hUCMSCs) in co-cult...

With the ability of tropism towards tumors, mesenchymal stem cells (MSCs) have been considered to be attractive delivering vehicles for antitumor therapy. Molecular imaging allows noninvasive tracking of molecular or cellular processes in vivo, as well as evaluation of targeted cancer therapy. We recently exploited bioluminescence imaging (BLI) and near infrared (NIR) imaging to evaluate the in...

Diabetes mellitus is a huge burden for several countries. No matter type I or type II diabetes, the insufficient of insulin causes the dysfunction of regulating blood sugar and leads to hypoinsulinemia and life threatening ketoacidosis. To our knowledge, no effective treatment to cure diabetes and most diabetic patients still need to rely on the long-term injection of insulin. Herein, we summar...

Mesenchymal stem cells (MSCs) have been considered as hypo-immunogenic and immunosuppressive. However, a thorough understanding of the immunological properties after MSC differentiation in vitro and in vivo has not been reached. We asked whether it would be immunogenic after differentiation or influenced by the immune microenvironment after transplantation. In different disease models, the immu...