Background: Diabetes mellitus often develops on the background of insulin resistance. High-intensity interval training (HIIT) is included in treatment diabetes since it increases sensitivity tissues to insulin. Objective: This paper aimed review published articles effects HIIT resistance diabetic patients. Method: A narrative literature was undertaken. provides evidence from human studies, whic...

Two methods (1, 2) for the immunochemical assay of circulating human insulin have been described recently. Both are based on the displacement of insulin-I131 from antibody by the addition of unlabeled insulin but differ in the conditions employed for the combination of insulin to antib)o(ly and for the subsequent separation of the bound from free insulin. Beef insulin was used as the reference ...

The radio-immunological technique for assaying endogenous plasma insulin in man recently described by Yalow and Berson (1, 2) promises to be of considerable value in the investigation of insulin metabolism. Other immunological methods that have been reported are not so sensitive as this method, since they fail to detect insulin in fasting normal human plasma (3). In contrast to the bioassay met...

Objective: The present study aimed to develop and characterize Chitosan coated Alginate Nanocapsules loaded with M-Insulin Concanavalin A Complex for glucose-responsive delivery. Methods: Preformulation studies were performed on the Insulin human recombinant prepared by ionic gelation method chitosan using electrostatic attraction. formulation variables optimized Box-Behnken design (BBD) help o...

Limiting excessive postprandial glucose excursions is an important component of good overall glycemic control in diabetes mellitus. Pharmacokinetic studies have shown that insulin aspart, which is structurally identical to regular human insulin except for the replacement of a single proline amino acid with an aspartic acid residue, has a more physiologic time-action profile (i.e., reaches a hig...

Insulin replacement therapy is the standard of care for patients with type 1 and advanced type 2 diabetes mellitus. Porcine and bovine pancreatic tissue was the source of the hormone for many years, followed by semisynthetic human insulin obtained by modification of animal insulin. With the development of recombinant DNA technology, recombinant (biosynthetic) human insulin became available in l...

OBJECTIVE Recent studies suggested an impact of prandial insulin delivery on postprandial regulation of tissue blood flow. This study compared the effect of VIAject with human regular insulin and insulin lispro on postprandial oxidative stress and endothelial function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Fourteen patients (seven men; aged 61.5 +/- 1.8 years; duration ...

Concurrent disorders with diabetes mellitus is one of the most challenging subject. Our knowledge of the most common concurrent disorders in diabetic dogs may be useful in diagnosis of these disorders and better treatment of diabetic dogs. In this study diabetes mellitus was diagnosed in a 7-year-old male German shepherd dog, based on clinical and laboratory findings. Following the diagnosis of...

Insulin production was studied in transgenic mice expressing the human insulin gene under the control of its own promoter. Glucose homeostasis during a 48-h fast was similar in control and transgenic mice, with comparable levels of serum immunoreactive insulin. Northern blot and primer extension analyses indicated that more than twice as much insulin mRNA is present in pancreata from transgenic...

UNLABELLED Absorption rates of phosphate buffered insulin analogs aspart and lispro prevail over regular human insulin. However, insulin aspart has not been widely used. The aim of this open controlled clinical study is to compare the metabolic effects of insulin aspart and phosphate buffered insulin when both are used in insulin pumps according to the identical algorithms. METHODS Twenty one...