Tumor antigen-reactive T cells can be detected in a large proportion of melanoma patients, but their efficacy on tumor control in vivo remains unclear. On the other hand, vitiligo, a skin disorder characterized by patchy depigmented macules, may occur spontaneously or after antitumor therapies. Moreover, vitiligo is significantly associated with positive clinical response, but the mechanism is ...

background: vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. the exact etiology and pathogenesis of vitiligo is not clear. many theories have been presented regarding this subject among them aautoimmune theory is the most important one. the association of vitiligo with other autoimmune disorders has been reported, but the relationship ...

Vitiligo is an autoimmune disease characterized by depigmented lesions on the skin, and T-cell mediated in that cytotoxic T-cells kill melanocytes, resulting lesional areas of skin depigmentation. Interferon gamma (IFN-γ) proposed to play a key role pathogenesis vitiligo. The Janus kinase (JAK)-signal transducer activator transcription factor (STAT) pathway downstream activated IFN-γ, thus util...

OBJECTIVE Vitiligo usually presented as asymptomatic depigmented macules and patches. Little is known regarding itch in vitiligo. This study aimed to evaluate the prevalence and characteristics of itch in vitiligo patients. PATIENTS AND METHODS A cross-sectional study was conducted on vitiligo patients. Itch character and intensity were determined through questionnaires. Evaluation was also m...

Tumor antigen-reactive T cells can be detected in a large proportion of melanoma patients, but their efficacy on tumor control in vivo remains unclear. On the other hand, vitiligo, a skin disorder characterized by patchy depigmented macules, may occur spontaneously or after antitumor therapies. Moreover, vitiligo is significantly associated with positive clinical response, but the mechanism is ...

BACKGROUND Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients. METHODS We performed a retrospective study on consecutive patient...

OBJECTIVE To determine whether the extent, distribution, and duration of vitiligo are associated with impairment of specific aspects of quality of life. DESIGN A prospective questionnaire-based study of 1541 adults with vitiligo. SETTING Online questionnaire. MAIN OUTCOME MEASURES Affected body surface area (BSA), distribution and duration of vitiligo, associated symptoms, and quality of ...

BACKGROUND Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis. AIM To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo. METHODS Nineteen patients with limited v...

The impact of vitiligo on quality of life is controversial. The aim of this study was to observe the impairment of quality of life and emotional state in adults with vitiligo compared with subjects with psoriasis and unaffected controls. The study group comprised 54 subjects with vitiligo, 57 with psoriasis and 57 unaffected controls. All subjects were examined and interviewed using the Dermato...

I read with interest and appreciated the paper of Kiniwa et al. (1), which was published in a recent issue of Cancer Research. They identified a novel melanoma/melanocyte antigen (KU-MEL-1), isolated from a patient with vitiligo and T-cell-infiltrated metastatic melanoma, that induced IgG responses in patients with various cancers and Vogt-Koyanagi-Harada disease but did not in 12 vitiligo pati...