Two new prenylchalcones, xanthohumol C and D, together with two known prenylchalcone derivatives, xanthohumol (1) and 5''-(2''-hydroxyisopropyl)-dihydrofurano-[2'',3''-b]-4,4'-dihydroxy-6'-methoxy-chalcone (4) were isolated and identified from the hops of Humulus lupulus L. The structures of xanhohumol C and D were elucidated as 5''-hydroxy-6'',6''-dimethyl-dihydropyrano-[2'',3''-b]-4,4'-dihydr...

6-prenylnaringenin (6pn) is a chiral prenylflavonoid found most prevalently in hops ( humulus lupulus ) and present in hops and hop products. it is an isomer of the potent phytoestrogen, 8-prenylnaringenin. an enantiospecific method for quantitation 6pn by lc-esi-ms has been developed. baseline enantiomeric resolution of 6pn was attained on a chiralpak ® ad-rh column with an isocratic mobile ph...

J. Am. Soc. Brew. Chem. 68(3):125-131, 2010 Genetic information for male and female hop accessions is limited, hampering parental selection to maximize offspring productivity. Our objective was to determine whether amplified fragment length polymorphism (AFLP)derived genetic distance (GDmm) estimates and coancestry estimates from pedigrees (GSped) between parental pairs could be used to predict...

The purpose of this study was to investigate the anxiolytic effects of xanthohumol, a component of Humulus lupulus (hops), and its potential interaction with the benzodiazepine binding site on the y-aminobutyric acid (GABAA) receptor in the male Sprague-Dawley rat. This was a prospective, randomized, between-subjects experimental study. Fifty-five rats were assigned to 1 Sof 5 groups with 11 ra...

Aroma compounds in Cascade and Chinook hops harvested from multiple Virginia locations were identified by gas chromatography-mass spectrometry-olfactometry (GC-MS-O) aroma extract dilution analysis (AEDA). Selected quantitated combination of stable isotope (SIDA) standard addition method (SAM). A total 33 aroma-active detected five samples with β-myrcene, methyl octanoate, geraniol linalool bei...