This study aims to determine the prevalence of and variation in cognitive deficits in systemic lupus erythematosus (SLE) patients with a prior history of central nervous system involvement (+Hx CNS), and without (-Hx CNS); and the relationship of SLE-related cognitive deficits to medication dosage and disease activity. Ninety-four participants, 62 SLE and 32 controls, were screened for anxiety ...

BACKGROUND HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a promising antioxidant with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the tolerability and pharmacokinetics of HX-1171 in healthy volunteers. METHODS A randomized, single-blind, placebo-controlled, dose escalation study was conducted in 83 subjects. In the single ascending dose study, 20,...

To examine the relationship between protein structural dynamics and measurable hydrogen exchange (HX) data, the detailed exchange behavior of most of the backbone amide hydrogens of Staphylococcal nuclease was compared with that of their neighbors, with their structural environment, and with other information. Results show that H-bonded hydrogens are protected from exchange, with HX rate effect...

Unprotected amide protons can undergo fast hydrogen exchange (HX) with protons from the solvent. Generally, NMR experiments using the out-and-back coherence transfer with amide proton detection are affected by fast HX and result in reduced signal intensity. When one of these experiments, (1)H-(15)N HSQC, is used to measure the (15)N transverse relaxation rate (R2), the measured R2 rate is convo...

Myelin formation and maintenance are crucial for the proper function of the CNS and are orchestrated by a plethora of factors including growth factors, extracellular matrix components, metalloproteases and protease inhibitors. Hemopexin (Hx) is a plasma protein with high heme binding affinity, which is also locally produced in the CNS by ependymal cells, neurons and glial cells. We have recentl...

In the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (n=6632), eplerenone-associated reduction in all-cause mortality was significantly greater in those with a history of hypertension (Hx-HTN). There were 4007 patients with Hx-HTN (eplerenone: n=1983) and 2625 patients without Hx-HTN (eplerenone: n=1336). Propensity scores for eplerenone use, separately c...

Messenger RNA levels of rat organic anion transporter 1 (Oat1; Slc22a6) and Oat2 (Slc22a7) in kidney and Oat3 (Slc22a8) in liver are gender-predominant. Oat1 and Oat3 are male-predominant, whereas Oat2 is female-predominant. Gonadectomized and hypophysectomized (HX) rats were studied to determine whether sex steroids and/or growth hormone (GH) are responsible for these gender-divergent patterns...

Let f be a measure-preserving transformation of a Lebesgue space (X,μ) and let F be its extension to a bundle E = X × R by smooth fiber maps Fx : Ex → Efx so that the derivative of F at the zero section has negative Lyapunov exponents. We construct a measurable system of smooth coordinate changes Hx on Ex for μ-a.e. x so that the maps Px = Hfx ◦Fx ◦H−1 x are sub-resonance polynomials in a finit...

We present BeppoSAX observations of the southern S1 region in the European Large-Area Infrared Space Observatory (ISO) Survey (ELAIS). These observations cover an area of D1.7 deg2 and reach an on-axis (D0.7 deg2) 2-10 keV (hard X-ray, or HX) sensitivity of D10~13 ergs s~1 cm~2. This is the Ðrst HX analysis of an ISOCAM survey. We detect nine sources with a signal-to-noise ratio four SNR HX [ 3...