treatment, biologically. Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3% & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1% & 2%) as polymers by solvent casting technique with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. Based on their physioche...

Pravastatin sodium is available for oral administration as 10 mg, 20 mg, 40 mg, and 80 mg tablets. Inactive ingredients include: colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, mannitol, meglumine, microcrystalline cellulose and starch. The 10 mg, 20 mg and 80 mg tablets also contain D&C Yellow No 10 Aluminium Lake and the 40 mg tablet also contains D...

Hydroxypropyl methylcellulose (HPMC) is a polymer made of cellulose backbone with etherified methoxy and hydroxypropyl substitutions that undergoes reversible inverse thermo-gelation upon heating. The follows two-step mechanism: first, phase separation occurs, then fibrils, formed in the polymer-rich phase, entangle to form three-dimensional gel network. This work aims at understanding influenc...

A multiple-unit formulation for time-dependent colonic release of insulin was obtained by coating insulin and sodium glycocholate immediate-release minitablets with: (i) Methocel® E50, a low-viscosity hydroxypropyl methylcellulose (inner coating), (ii) 5:1 w/w Eudragit® NE/Explotab® V17, a mixture of a neutral polymethacrylate with a pore-forming superdisintegrant (intermediate coating), and (i...

Objective: The present research is focused on developing flurbiprofen colon-specific tablets based on timed release and pH-sensitivity. Methods and Material: This study is designed to study the effect of eudragit coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the colon-specific release. Hydroxypropyl methylcellulose matrix tablets were prepared by wet granulati...