The objective of this study is to evaluate the effect of formulation variables on different evaluation properties such as cumulative percentage release and swelling index in development of two layered buccal mucoadhesive system consisting of a highly water soluble drug risedronate sodium. The mucoadhesive systems were developed with varied concentrations of the polymers (1-2%) using plasticizer...

The aspire of this attempt was to design and evaluate aceclofenac loaded sustained release microspheres by emulsion solvent evaporation method, using different polymers like Ethyl cellulose (EC), Kollidon SR (KSR), Eudragit RS 100, Eudragit RL 100 and Hydroxypropylmethyl Cellulose (HPMC K100M). Microspheres were prepared using different stirring rate (1200, 1500, 2000rpm) and larger microsphere...

Floating matrix tablets of Glimepiride were developed to enhance its bioavailability by prolonging the gastric residence time in which Glimepiride was chosen as a model drug because of its has incomplete absorption due to its low gastric residence time. Floating matrix tablets were prepared using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmeth...

Antibacterial SiO2 hybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropylmethylcellulose (HPMC) and silver were prepared by the sol-gel method. The content of cellulose derivate was 5 wt% and the silver concentration varied from 0.5 wt% to 2.5 wt%. The amorphous nature, morphology and antibacterial behaviour were studied. Fourier transform infrared (FTIR) spectra of the hybrid...

In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form supersaturated solutions and to identify the effects of supersaturation on increasing the bioavailability of dutasteride. The excipients included Eudragit E, hydroxypropyl-β-cyclodextrin (HP-β-CD), ...

The aim of this study was to measure the gas permeability of edible films using a homemade experimental apparatus and to determine the respiration rate of tomatoes (L. esculentun var. Cerasiforme) without (NC) and with (CC) edible coating at different temperatures. Permeability was determined using an experimental device according to the ASTM D1434 method and the apparatus was validated using p...