This work assesses the in vitro antimicrobial activity of an aqueous olive mill waste extract (AE-2) on growth diverse cocktails foodborne pathogens species (Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella Enterica). The effects were evaluated by Response Surface Methodology, using a two-block (D-optimal full factorial) sequential design, with two independent var...

Autochthonous strains belonging to Lacticaseibacillus paracasei and casei were screened based on pro-technological (kinetics of growth acidification, exopolysaccharides biosynthesis), functional (cell viability during processing storage, in vitro protein digestibility, gastrointestinal batch digestion), sensory properties ferment milk intended be included the ice-cream formulation. The main dis...

Oleuropein and other phenolic compounds contained in olive leaves give it the potential to be transformed from residue co-product an oil mill. However, moment of agronomic cycle which their transformation is higher not known detail. Therefore, for first time, a monthly study evolution such throughout made (November 2019 October 2020). Arbequina were collected three plots interactive effects con...

In this study, the effect of cultivar, harvest year, and geographic regions (Mediterranean, Aegean, Southeastern Anatolia, Marmara, Black Sea) on phenolic compounds virgin olive oils were investigated. Tyrosol was major compound in Mediterranean, Southeastern, Sea regions. Hydroxytyrosol showed highest value (2.07 mg/kg) Anatolia region lowest (0.75 Marmara region. Among acids, vanillic acid ha...

background: renal ischemia reperfusion (ir), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. the aim of this study was to investigate the effects of hydroxytyrosol (ht) on renal ischemia-reperfusion injury in mice. methods: male mice were randomly assigned to three groups (n = 9): (1) sham operated, (2...

2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated me...

Background: Due to high mortality of patients with metastatic breast cancer and limited strategies for management this malignancy, development novel therapeutic approaches anti-cancer agents is essential. Objectives: In the present study, we investigated in vitro anti-proliferative effects hydroxytyrosol, as a natural chemotherapeutic agent, against cells MDA-MB-231 MCF-7. Methods: The anti-pro...