46,XX gonadal dysgenesis is a rare genetically heterogeneous disorder characterized by underdeveloped ovaries with consequent, impuberism, primary amenorrhea, and hypergonadotropic hypogonadism. Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in a woman with normal development of sec...

We present a report on two sisters who have 17 ƒ¿-hydroxylase deficiency with hyperaldosteronism. They have hypertension and hypergonadotropic hypogonadism. The steroid profiles suggest that they have 17 ƒ¿-hydroxylase deficiency. In contrast to the classical biochemical findings in 17 a-hydroxylase deficiency, both of these patients have hyperaldosteronism. Thus this report describes a new var...

We report a 27 -year-old male referred because of hypergonadotropic hypogonadism with low testosterone and azoospermia. At 23 years age, he underwent an excision hypoechoic 0.7 cm nodule the left testicle. The pathological diagnosis was Leydig cell tumor. In right testicle, there were three nodules at ultrasound, biggest measuring 0.6 cm. Four later, in testicle still present larger excised. bi...

Premature ovarian failure (POF) is the term usually used to describe women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility. POF is a devastating diagnosis for reproductive-aged women. The clinical presentation is diverse, and several different disorders can lead to premature ovarian failure. POF has serious health consequences, including...

The clinical examination revealed a size 145 cm (-3 SD/M. SEMPE) with a total impuberism. The hormonal tests showed a hypergonadotropic hypogonadism. The abdominal CT scan revealed a left hemi-abdominal mass with a large vascular pedicle (supernumerary spleen?) Figure 1. Our patient was followed for cardiac heart failure. The echocardiographic exploration found a left systolic ventricular dysfu...

INTRODUCTION This article, Part 1 of the Endocrine Society of Australia's position statement on male hypogonadism, focuses on assessment of male hypogonadism, including the indications for testosterone therapy. (Part 2 will deal with treatment and therapeutic considerations.) MAIN RECOMMENDATIONS Key points and recommendations are:Pathological hypogonadism arises due to diseases of the hypoth...