INTRODUCTION I t is well known that the strict control of serum inorganic phosphorus (IP) and potassium (K) concentrations is important for the prevention of various complications and improving the prognosis of patients with chronic kidney disease (CKD). Hyperkalemia is associated with sudden cardiac death in hemodialysis (HD) patients and hyperphosphatemia is associated with an increase in car...

The irreversible FGFR1–4 inhibitor futibatinib has demonstrated efficacy in patients (pts) with intrahepatic CCA (iCCA) FGFR2 fusions/rearrangements along a manageable safety profile pivotal phase II study. Here, we report an integrated E–R analysis of and efficacy. Pts advanced solid tumors receiving once daily (QD; 4–24mg) or thrice weekly (TIW, 8–200 mg) global I/II study (NCT02052778) Japan...

INTRODUCTION Adequate dietary phosphorus intake and the use of phosphorus binders are the main tools for treating hyperphosphatemia. Thus, its success depends essentially on the patient's ability to understand and adhere to the dietary plan and the use of phosphate binders. OBJECTIVE To evaluate hyperphosphatemic patients adherence and knowledge about phosphate control treatment. METHODS Th...

Patients with chronic renal failure have many associated medical problems, including a high propensity for cardiovascular disease (CVD). CVD and stroke are the leading causes of mortality in patients with ESRD (chronic kidney disease stage 5), with a 10to 20-fold greater risk than in the general population (1,2). These data have generated greater awareness of cardiovascular risk in the chronic ...

Tumoral calcinosis is a rare disorder that presents with ectopic calcifications deposited at different periarticular soft tissue regions of the body- mostly hips, elbows and shoulders. It results from relative deficiency of, or resistance to, phosphate-regulating hormone - Fibroblast Growth Factor 23 (FGF23), due to gene mutations, causing hyperphosphatemia. We describe this condition in 13 yea...

BACKGROUND AND OBJECTIVES Phosphate control impacts dialysis outcomes. Our aim was to define peritoneal phosphate transport in peritoneal dialysis (PD) and to explore its association with hyperphosphatemia, phosphate clearance (PPhCl), and PD modality. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Two hundred sixty-four patients (61% on continuous ambulatory PD [CAPD]) were evaluated at month...

Hyperphosphatemia is related to some pathologies, affecting vascular cell behavior. This work analyzes whether high concentration of extracellular phosphate induces endothelial senescence through up-regulation of endothelin-1 (ET-1), exploring the mechanisms involved. The phosphate donor β-glycerophosphate (BGP) in human endothelial cells increased ET-1 production, endothelin-converting enzyme-...

BACKGROUND The implications of chemical hyperparathyroidism on bone and mineral metabolism measures in maintenance hemodialysis (MHD) are not well known. We hypothesized that a higher serum intact parathyroid hormone (iPTH) level is associated with the higher likelihood of hyperphosphatemia, hyperphosphatasemia [high serum alkaline phosphatase (ALP) levels] and hypercalcemia. METHODS Over an ...

BACKGROUND Hyperphosphatemia, serum phosphorus ≥ 4.4 mg/dL, is associated with increased risk for chronic kidney disease and cardiovascular disease. Previous studies have shown a weak association between dietary phosphorus intake and serum phosphorus concentrations. While much less common in the general population, hypophosphatemia (< 2.5 mg/dL) may be associated with metabolic syndrome and obe...