Since the beginning of micro-RNA (miR) research, several attempts have been made to identify the ‘melano-miRs’, which are involved in melanoma progression. Indeed, a small number of miRs have been identified to regulate some genes involved in melanogenesis. However, the miRs that control the pathway to the malignant phenotype are yet undescribed. In this issue of the EMBO Journal, Penna et al (...

hysteroscopy is a new and precise method for evaluating of uterus, so it is valuable in evaluating infertile women. in 18 months, 363 hysteroscopies were done on patients who were visited in ivf center of shariati hospital for treatment of infertility. incidence of abnormal hysteroscopy was 18%. 32% of these abnormal hysteroscopies was endometrial hyperplasia. in evaluating of laparoscopy and o...

conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...

Eosinophilic cholecystitis (EC) is a rare entity that presents in a manner comparable to acute cholecystitis. The diagnosis is based on classical symptoms of cholecystitis with the presence of eosinophils (>90%) within the gallbladder. EC has been reported alone (idiopathic EC) or in combination with manifestations such as eosinophilic cholangitis, hypereosinophilic syndromes, and parasitic inf...

eosinophilic cholecystitis (ec) is a rare entity that presents in a manner comparable to acute cholecystitis. the diagnosis is based on classical symptoms of cholecystitis with the presence of eosinophils (>90%) within the gallbladder. ec has been reported alone (idiopathic ec) or in combination with manifestations such as eosinophilic cholangitis, hypereosinophilic syndromes, and parasitic inf...

prostatic intra-epithelial neoplasia (pin) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. in this study, we applied the pin grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of pro...

we report two cases of focal nodular hyperplasia in patients following gadoxetic acid (gd-eob-dtpa)-enhanced magnetic resonance imaging confirmed with histopathology. these cases showed an atypical pattern during the delayed-hepatobiliary phase after the injection of gadoxetic acid. one case showed a total defect, and the other showed a peripheral ring-like enhancement without a visible central...

we described a case of lymphoid follicular hyperplasia that arose from the ileum of a 52-year-old woman. her colonoscopy revealed a large mass in the cecum associated with multiple polypoid lesions in the ileum. histologic examination demonstrated severe lymphocytic infiltration and lymphoid follicles with regular germinal centers, without evidence of malignancy. a right hemicolectomy was perfo...

statement of problem: in recent years, numerous reports have been presented in the literature, about gingival overgrowth induced by nifedipine- a calcium antagonist- prescribed for hypertension and certain types of angina. purpose: the purpose of the present study was to investigate the prevalence rate of nifedipine induced gingival hyperplasia in patients and its probable relationship with age...