Acanthosis nigricans (AN) is a lesion affecting localized areas of the skin in persons with obesity and/or hyperinsulinemia. Biochemical mechanisms responsible for developing this hyperplastic lesion are unclear, but likely involve local cutaneous growth factors. It is associated with obesity, endocrinopathies (insulin resistance, diabetes mellitus, Cushing disease and acromegaly) and visceral ...

We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20-methylcholanthrene (20-MC) to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice. The lesions were examined histologically and immunohistochemically with anti-single-stranded DNA after acid hydrolysis (DNA-instability test), p53, VEGF, DFF45, PCNA an...

Hyperplastic polyps of the stomach are regarded as benign. However, in rare cases they may contain incipient primary carcinomas. To our knowledge, breast carcinoma metastatic to a gastric hyperplastic polyp has not yet been reported. We describe the case of a 69-year-old woman to whom a gastric polyp was endoscopically excised. The patient had previously undergone a right mastectomy for mixed, ...

Peritumoral hyperplasia (PTH) is a hyperplastic lesion located around hypervascular tumors. Hepatic sclerosed hemangioma is a very rare form of hemangioma with sclerotic changes and is distinct from sclerosing hemangioma. We present a patient with non-alcoholic steatohepatitis-induced cirrhosis who presented with a hypervascular tumor. The tumor showed atypical findings of hemangioma and was tr...

A slowly enlarging gingival mass with a reddish-purple surface is observed in a school-age boy. The lesion was first noted 3 months ago during a routine oral examination but recently it has increased in size and interferes with eating. A periapical radiograph demonstrated focal loss of the alveolar crestal bone in the mandibular incisor region. The diagnosis of peripheral giant cell granuloma, ...

Aim: Sessile serrated lesions (SSL) have the potential for malignant transformation into colorectal carcinoma (CRC), which develops via pathway of carcinogenesis. Material and Methods: Based on colonoscopy pathology reports, all sessile or polyps in risk screening group were studied at an urban medical research center between July 2018 2022. We prospectively included consecutive classified as a...

Sir, Recently, De Giorgi V et al. published an interesting clinical picture titled ‘Hyperplastic oral candidiasis of the tongue’. I read this article with great interest and compliment the authors for their clinical report. However, I would like to highlight several important issues. We should analyze carefully when the authors state, ‘Clinically, it is nearly impossible to differentiate such l...

Sir, Recently, De Giorgi V et al. published an interesting clinical picture titled ‘Hyperplastic oral candidiasis of the tongue’. I read this article with great interest and compliment the authors for their clinical report. However, I would like to highlight several important issues. We should analyze carefully when the authors state, ‘Clinically, it is nearly impossible to differentiate such l...

AbsractGastritis cystic polyposa is a rare and peculiar polypoid lesion arising at a gastroenterostomysite, and almost always on the gastric side. It is characterized by elongationof the gastric foveolae along with hyperplasia and cystic dilatation of the gastricglands extending into the submucosal layer. Esophagogastroduodenoscopy in a47-year-old woman without any history of gastric operation ...

Serrated adenomas are the precursors of at least 5.8% of colorectal cancers; otherwise little is known of their clinical significance in comparison with conventional adenomas and hyperplastic polyps. We compared the risk of metachronous lesions in colorectal serrated adenomas, conventional adenomas, and hyperplastic polyps. A consecutive series of patients with colorectal polyps first diagnosed...