Gastrointestinal stromal tumors (GISTs) are uncommon tumors of the gastrointestinal (GI) tract. Regorafenib is a new multikinase inhibitor and is approved for the treatment of GISTs in patients who develop resistance to imatinib and sunitinib. The most common drug-related adverse events with regorafenib are hypertension, hand-foot skin reactions, and diarrhea. Grade IV hypertensive side effect ...

was treated as a case of acute pancreatitis. Within seven days her condition was greatly improved and blood pressure was stable at around 130/70 mm Hg. Serum enzyme activities returned to normal. On 27 August and 31 October she had further episodes of abdominal pain, nausea, sweating, and headache accompanied by high blood pressure, high plasma catecholamine concentrations, and hyperamylasaemia...

signs. The chest was clear to auscultation, and heart sounds were normal without murmurs. The abdomen was plain and not tender, without masses or organomegalies. Results of urinalysis, complete blood count, serum electrolyte levels, hepatic-function and renal-function tests showed no abnormalities. A 24-h ambulatory blood pressure monitoring was then performed (Spacelabs 90207-30, with recordin...

Pulmonary arterial hypertension (PAH) is associated with significant perioperative risk for major complications, including pulmonary hypertensive crisis and cardiac arrest. Several mechanisms of hemodynamic deterioration, including acute increases in pulmonary vascular resistance (PVR), alterations of ventricular contractility and function and coronary hypoperfusion can contribute to morbidity....

Phaeochromocytoma is a catecholamine producing tumour and an uncommon cause of hypertension. We present two cases of relatively asymptomatic individuals, in which previously undiagnosed phaeochromocytoma was unmasked by elective nonadrenal surgical procedures, manifesting as postoperative hypertensive crisis and subsequent cardiogenic shock. The initial management in intensive care is discussed...

Ectopic secretion of adrenocorticotropic hormone (ACTH) is an infrequent cause of Cushing's syndrome. We report a case of ectopic ACTH syndrome caused by a pheochromocytoma. A 53-year-old female with clinical features of Cushing s syndrome presented with serious recurrent hypertensive crisis. Endocrinological investigation confirmed the diagnosis of ectopic ACTH production and revealed markedly...

Hypertensive crisis is a serious condition that results in target-organ damage, such as stroke, heart attack, or renal failure, if left untreated.1 Causes of acute increases in blood pressure in patients with primary essential hypertension include medication noncompliance and poorly controlled chronic hypertension. Treatment of a hypertensive crisis should be tailored to each individual based o...

A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of the tumor and continued to occur subsequent to the tumor being removed. The vi...

BACKGROUND Although uncommon, esthesioneuroblastomas may produce clinically significant amounts of catecholamines. METHODS We report a patient with a catecholamine-secreting esthesioneuroblastoma who developed an intraoperative hypertensive crisis. RESULTS A patient with a history of hypertension was referred to our skull base center for management of a residual esthesioneuroblastoma. A sta...