Tooth agenesis denotes a condition where teeth are missing due to a developmental failure. According to severity, this malformation can be subdivided into hypodontia, oligodontia and anodontia. With a frequency of 20–30%, tooth agenesis is the most prevalent dental dysplasia, but not all teeth are equally affected. Familial occurrence and concordance in twins indicate potential genetic causes. ...

To evaluate the association between paired box 9 (PAX9) gene polymorphisms and tooth agenesis in isolated humans, we performed a comprehensive meta-analysis. We examined 6 case-control studies, with a total of 855 hypodontia cases and 1201 healthy controls. The G allele and G carrier (AG + GG) of A1031G were positively associated with hypodontia susceptibility. Similarly, the T allele and T car...

Hypodontia is caused by interactions among genetic, epigenetic, and environmental factors during tooth development, but the actual mechanism is unknown. DNA methylation now appears to play a significant role in abnormal developments, flawed phenotypes, and acquired diseases. Methylated DNA immunoprecipitation (MeDIP) has been developed as a new method of scanning large-scale DNA-methylation pro...

Background: Hypodontia is one of the frequently observed dental anomalies in which dentofacial esthetics, phonetics, mastication, self-esteem and quality life can be adversely affected. Awareness disproportionate tooth number important must considered by orthodontists while making treatment plans to achieve proper occlusion, overbite, overjet, order restrain oral health deterioration. The aim t...

There is currently no specific occlusal index related to hypodontia and there is a paucity of published literature on this subject. The aim of this study was to determine the relationship, if any, between the Peer Assessment Rating (PAR) Index, the Index of Complexity, Outcome and Need (ICON), and the Dental Aesthetic Index (DAI) score and the severity of hypodontia. All new patients attending ...

Although hypodontia and supernumerary teeth are often considered as mutually exclusive conditions, this case report presents an unusual case of hypodontia and a supernumerary tooth occurring simultaneously. An adolescent male was referred to the local hospital department regarding upper arch crowding. Plain film radiographs confirmed the congenital absence of both lower lateral incisors in addi...

"Concomitant hypodontia and hyperdontia" is a very rare dental anomaly of number, having a prevalence rate of 0.002%-3.1%. It describes the simultaneous presence of hypodontia or missing teeth and supernumerary teeth in the same individual. It represents the opposite forces of nature acting simultaneously. Two rare cases of this anomaly involving different jaws and a classification based on the...

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BACKGROUND Hypodontia is the most common dental anomaly and might cause clinical complications. The aim of this study was to assess the prevalence and pattern of congenital missing in the permanent dentition dentition (excluding third molars), among Iranian orthodontic patients. MATERIALS AND METHODS In this descriptive cross-sectional study, all approved panoramic radiographs of 3374 orthodo...