The symptoms produced by hypoglycaemia in the newborn include apnoeic attacks, alterations of muscle tone, 'juddery' movements of the limbs, convulsions, and reluctance to feed. These symptoms are not specific for hypoglycaemia, for they can be caused by a variety of conditions, such as perinatal anoxia, intracranial haemorrhage, meningitis, or hypocalcaemia. When infants with both hypoglycaemi...

introduction: a growing number of muslim athletes now engage in international competition. this raises the question of the advice they should be given if a major event occurs during the month of ramadan. methods: a narrative review has been based upon books and extensive reviews completed by the author and other investigators. results: practical considerations hamper assessment of the effects o...

BACKGROUND Severe hypoglycaemia still represents a significant problem in insulin-treated diabetes. Most patients do not experience severe hypoglycaemia often. However, 20% of patients with type 1 diabetes experience recurrent severe hypoglycaemia corresponding to at least two episodes per year. The effect of insulin analogues on glycaemic control has been documented in large trials, while thei...

In non-diabetic adult patients, hypoglycaemia may be related to drugs, critical illness, cortisol or glucagon insufficiency, non-islet cell tumour, insulinoma, or it may be surreptitious. Nevertheless, some hypoglycaemic episodes remain unexplained, and inborn errors of metabolism (IEM) should be considered, particularly in cases of multisystemic involvement. In children, IEM are considered a d...

Martin, F. I. R., Dahlenburg, G. W., Russell, J., and Jeffery, P. (1975). Archives of Disease in Childhood, 50, 472. Neonatal hypoglycaemia in infants of insulin-dependent diabetic mothers. Neonatal hypoglycaemia (blood glucose <20 mg/100 ml) occurred in the first 6 hours of life in 25 of 34 infants born to diabetic mothers receiving insulin. Despite severe hypoglycaemia (blood glucose <10 mg/1...

UNLABELLED BACKGROUND Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic patients and identify predictors of hypoglycaemia when treatment is intensified. METHODS DiaRegis is a prospective German registry that follows 3810 patients with type-2 diabetes referred for treatment intensification becaus...

Hyperinsulinaemic hypoglycaemia (HH), which causes persistent neonatal hypoglycaemia, can result in neurological damage and it's management is challenging. Diazoxide is the first-line treatment, albeit not all patients will fully respond to it, as episodes of hypoglycaemia may persist and it entails unpleasant adverse effects. Sirolimus, an mTOR inhibitor, has reportedly been successful in trea...

BACKGROUND Central pontine myelinolysis (CPM) usually presents in chronic alcoholics and in patients in whom hyponatraemia has been corrected rapidly. However, CPM may occur in other clinical circumstances, including patients with severe hypoglycaemia. We describe the occurrence of CPM and quadriplegia in a patient who experienced fluoroquinolone-associated severe hypoglycaemia. CASE REPORT A...

AIMS To measure the prevalence of hypoglycaemia among newborn infants in Nepal, where classic risk factors prevail, and to evaluate their importance. METHODS A cross sectional study was done of 578 term newborn infants aged 0 to 48 hours on the postnatal wards of a government maternity hospital in Kathmandu, with unmatched case-control analysis of risk factors for moderate hypoglycaemia (less...

Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convulsion) and moderate (requiring assistance for treatment) hypoglycaemia were st...