the rhizome of anemarrhena asphodeloides is used as food and traditional chinese medicine for its hypoglycemic effect. the aim of this study was to investigate the isolation, purification and hypoglycemic activity of anemaran as the active component. the influence factors (isolation duration, ratio of residuals to water and extracting times) during the isolation process were evaluated. the opti...

Medicinal herbs, used in indigenous medicines in crude forms for the management of diabetes mellitus, contain both the organic and inorganic constituents. The aim of the study was to find out the hypoglycemic effect of Ficus racemosa in a group of diabetic subjects taking oral hypoglycemic drug. Twenty five of each, male and female, diabetic patients, selected from Fatima Jinnah Medical College...

of a dissertation at the University of Miami. The combination of bone morphogenetic protein 7 (BMP7) and neurotrophins (e.g. brain-derived neurotrophic factor, BDNF) protects septal neurons during hypoglycemic stress. I investigated the signaling mechanisms underlying this synergistic protection. BMP7 (5 nM) increased phosphorylation and nuclear translocation of BMP-responsive Smads 1/5/8 withi...

background and objectives: calamus rotang is used in traditional medicine. regarding the previous phytochemical screening of methanol extract of calamus rotang l. fruits (mcr), this study was performed to find out the antidiarrheal and hypoglycemic effects of the experimented extract in rodents. methods: castor oil induced diarrheal test was followed for screening anti-diarrheal effect of mcr. ...

The mechanism of the hypoglycemic activity of endotoxin in hyperreactive BCG mice was investigated. The mechanism was found to be an inhibition of the synthesis of glucose from noncarbohydrate sources. The possibilities of an induced hypermetabolic state and an induced release of insulin in response to endotoxin as causes for the hypoglycemic response were essentially ruled out. In addition, no...

A series of novel 2, 4-thiazolidinedione derivatives 2-{4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl] phenoxy}N-(substituted phenyl) acetamides d (1-12) have been accomplished in good yields by stirring 2,4-thiazolidinedione a and 2-(4-formyl phenoxy) N-substituted acetamide c (1-12) at room temperature. Some of the reaction sequences were carried under microwave irradiation which resulte...

Several medicinal plants are having hypoglycemic effects.[1], The World Health Organization has recommended that the assessment of traditional plant treatments for diabetes mellitus needs further investigation.[2], Several herbal medicines were described for the care of diabetes mellitus in ancient literature of Ayurveda in India. Many of the plants used as diet were reported to have antidiabet...

Insulin and insulin-like growth factors I and II (IGF-I and IGF-II) have recently been shown to have biological activity in central neurons, but their normal functions and mechanisms of action in the brain are unknown. Since central neurons are particularly vulnerable to hypoglycemia that results from ischemia or other insults, we tested the hypothesis that growth factors can protect central ne...