Romalea guttata Houttuyn (= R. microptera Beavois) is flightless, lethargic, aposematic, and chemically defended. R. guttata stores large quantities of two adipokinetic hormone (AKH) family peptides in its corpora cardiaca. In adults, these peptides (Rom-CC-I and Grb-AKH) activate fat body glycogen phosphorylase but are not hypertrehalosemic. Because juvenile R. guttata contain sufficient pepti...

Olive mill wastewater (OMW) is one of the most environmentally concerning food processing effluents due to its phytotoxicity. Recently, several bioactive compounds with potential applications in food, pharmaceutical, and agricultural industries have been identified OMW. This study aimed compare, for first time, physico-chemical characteristics biological activity OMW obtained by two different t...

BACKGROUND AND PURPOSE We compared the levels of serum lipid, protein, and glucose between patients with amyotrophic lateral sclerosis (ALS) and healthy controls. METHODS The serum levels of lipids [including triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], protein, and glucose of 95 patients with ALS (60 men) were compared with those of 99 age- ...

Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable rare skin fragility disorder characterized by deficient dermo-epidermal adhesion due to mutations in COL7A1 gene. Modifying genes and epigenetic factors, mainly associated with inflammation, contribute clinical severity, are key the design of novel effective therapies. The goal this omics study expand knowledge molecular mechanis...

For more than 3,000 years, Withania somnifera, commonly known as Ashwagandha, has been utilised in traditional and Ayurvedic medicine. It belongs to the ginger family. Dry powder, crude extract, refined metabolites of plant have all demonstrated potential therapeutic advantages animal trials because it is a medicinal plant. Withanolides are primary plant, they responsible for effects herb. Desp...

Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after the consumption of a diet rich in fat, sucrose, and cholesterol. To examine whether SIK3 can modulate glucose and lipid metabolism in the liver, we analyzed phenotypes of SIK3-deficent mice. Sik3(-/-) mice have a malnourished the phenotype (i.e., lipodystrophy, hypolipidemia, hyp...

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor 4α (HNF4α), a liver-enriched nuclear hormone receptor, is markedly inhibited, whereas miR-34a is highly induced in patients with non-alcoholic steatohepatitis, diabetic mice and mice fed a high-fat diet. miR-34a is ess...

42 43 Dietary fat is an important mediator of atherosclerosis and obesity. Despite its 44 importance in mediating metabolic disease, there is still much unknown about 45 dietary fat absorption in the intestine, and especially the detailed biological roles 46 of intestinal apolipoproteins involved in that process. We were specifically 47 interested in determining the physiological role of the in...

OPPT has been assessing perfluor,inated compounds since 1999. This interest was prompted by reports submitted to the agency describing the toxic properties and widespread presence in the environment, including in human populations, of some of these chemicals. Initial efforts focused on perfluorooctane sulfonate (PFOS), and the assessment of ecological and human health hazards was recently publi...