OBJECTIVE To determine Topiramate efficacy on treatment of infantile spasms and ancillary seizures, and whether there were any improvements on EEG. METHODS A retrospective study of 18 patients with infantile spasms recruited from the Pediatric Unit at King Fahd Hospital of the University, Dammam University, Saudi Arabia was carried out between January 2004 and December 2008. Topiramate was us...

Annotations Seizures and steroids For over 40 years we have known that some children with otherwise intractable fits improve with steroids, ' and for over 30 years that a similar response may be obtained with adrenocortico-trophic hormone.2 Since that time a considerable amount of work has centred on infantile spasms, particularly on the relative efficacies of prednisone and adrenocorticotrophi...

Objective To study the epilepsy syndromes among severe epilepsies of infancy and assess their incidence, etiologies, outcomes. Methods A population-based cohort was undertaken with onset before age 18 months in Victoria, Australia. Two epileptologists reviewed clinical features, seizure videos, electroencephalograms to diagnose International League Against Epilepsy syndromes. Incidence, outcome...