We examined the merits of combinatorial hMUC1 vaccination and hNIS radioiodine gene therapy and evaluated its tumoricidal effects in an animal tumor model. CMNF (CT26 expressing hMUC1, hNIS, and firefly luciferase) cells were transplanted into 28 mice, and 4 and 11 days after tumor challenge, tumor-bearing mice were immunized i.m. with pcDNA3.1 or pcDNA-hMUC1 vaccine and subsequently administer...

CONTEXT Data from a large cohort of patients with pulmonary metastases from differentiated thyroid cancer (DTC) were retrospectively analyzed. OBJECTIVE To assess the effect of radioiodine therapy and investigate the prognostic factors of survival for patients with pulmonary metastasis secondary to DTC. METHODS A total of 372 patients with pulmonary metastasis from DTC treated with (131)I e...

Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into ~8 dogs with spontaneous tumors. The I TM content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I TM. In a few instances preferential 1 in localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in ...

Radioiodine (I-131) therapy is of proven efficacy for treatment of differentiated thyroid carcinoma (DTC). However, loss of differentiation in recurrent or metastatic DTC which decrease I-131 uptake may decrease the efficacy of I-131 therapy. Therefore, strategies to improve I-131 uptake are mandatory. This study is an open label clinical study to evaluate the effectiveness of 13-cis retinoic a...

differentiated thyroid carcinomas usually show good uptake and response to i-131 ablative treatment. in this study, 90 patients following near total thyroidectomy who were referred to our institute for i-131 therapy are retrospectively studied. the patients are divided in two groups. group 1 revealed complete ablation after one dose of i-131. group 2 needed more than one dose of i-131 for ablat...

The aim of this study was to evaluate the influence of I-131 therapy on pregnancy outcome in patients that received therapeutic I-131 doses for thyroid cancer in Taiwan.This nationwide population-based cohort study was based on data from 1998 to 2010 obtained from the Taiwanese National Health Insurance Research Database. We identified 11,708 women with thyroid cancer (≥ 15 and ≤ 50 years of ag...

in this report, the clinical course and treatment response of 210 patients with grawes’ disease referred to the research institute for nuclear medicine were studied. the disease was more common in 3rd and 4th decades and more frequent in women (f/m=4). treatment response with antithyroid drugs was about 50%, whereas 80% of the patients treated by i-131 showed positive response. there was no mea...

Monitoring of air and milk samples is done routinely around nuclear facilities that release iodine-131 to the environment. Results from these measurements are used to calculate dose rates to the thyroids of people who live near such facilities. These calculated dose rates have large uncertainty factors associated with them due to the complexity of predicting the movement of iodine-131 through t...