Pulmonary fibrosis is caused by various known and unknown aetiologies, but the key pathogenic mechanisms are still ill-defined. Chemokines are a large family of chemotactic cytokines that play pivotal roles in various inflammatory diseases. In the present study, the roles of chemokines in a rat model of radiation pneumonitis/ pulmonary fibrosis were examined. Accumulation of inflammatory cells ...

Further characterisation of computed tomographic and clinical features for staging and prognosis of idiopathic pulmonary fibrosis in west highland white terriers T 2017, 'Further characterisation of computed tomographic and clinical features for staging and prognosis of idiopathic pulmonary fibrosis in west highland white terriers' Veterinary Radiology & Ultrasound. Publisher Rights Statement: ...

Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3-5 years is still 50%. Autophagy, a highly conserved homeostatic mechani...

Background & Objective: Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study Epstein-Bar Virus (EBV) and Human Herpesvirus 8 (HH...

Background and Objectives: Idiopathic pulmonary fibrosis (IPF) is characterized by progressively worsening lung function, ventilation capacity, dyspnea, and finally reduced exercise intolerance. All of these have a significant negative impact on functional capacity and quality of life. In this study, we aim to evaluate the effects of pulmonary rehabilitation (PR) in IPF and assess the predictor...

Lung transplantation is an accepted therapy for patients with end-stage lung disease and offers a major survival benefit in selected patients. The most important indications are chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis besides cystic fibrosis and pulmonary arterial hypertension. The incidence of lung cancer in patients after Ltx is 20-25 times higher than in the g...

  Objective(s): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an...

Pulmonary aspergilloma (mycetoma) usually is a
 saprophytic fungal infection due to aspergillus species
 which colonized and grows into pre-existing cystic/
 cavitary lesions resulting from pulmonary tuberculosis
 or fibrotic sarcoidosis, other fibro-cavitary diseases
 including interstitial lung diseases. Idiopathic pulmonary
 fibrosis (IPF) a rare, chronic, progr...

In the American Thoracic Society/European Respiratory Society consensus classification, idiopathic interstitial pneumonias are classified into seven clinicopathologic entities. The classification is largely based on histopathology, but depends on the close interaction of clinician, radiologist, and pathologist. An accurate diagnosis can be very difficult, especially when deciding between idiopa...

results the administration of quercetin hydrate significantly reduced the concentration of il-13, pdgf-β, and tnf-α and increased the concentrations of inf-γ in balf. conclusions according to the experimental results, quercetin hydrate reduced the concentration of inflammatory fibrotic factors, such as il-13, pdgf-β, and tnf-α, and increased the level of the antifibrotic factor inf-γ, and the e...