The aim of the research was to determine differences in IL-1ß, IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α and IL-1ra blood concentrations pregnant non-pregnant healthy mares. mares were divided into two groups: (n = 18; age 6.11 ± 2.25 years); 6; 5.67 1.75 years). Blood samples collected from all 24) three times every month, then group subgroups based on pregnancy (1st 6)—6th, 7th, 8th; 2nd 6)—7th,...

OBJECTIVE To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. METHODS This was a prospective, randomized trial of 60 patients assigned to either roller pump (...

The unique physical and chemical properties of nanomaterials have led to their increased use in many industrial applications, including as a paint additive. For example, titanium dioxide (TiO2) engineered nanoparticles (ENPs) have well-established anti-UV, self-cleaning, and air purification effects. Silver (Ag) ENPs are renowned for their anti-microbial capabilities and silicon dioxide (SiO2) ...

Introduction Cryopyrin-associated periodic syndrome (CAPS) is a rare systemic, monogenetic inherited autoinflammatory condition caused by NLRP3/CIAS 1 gene mutations encoding for cryopyrin, a major component of the inflammasome, leading to an excessive production of interleukin-1beta (IL-1ß). The clinical picture of genetic variations of the NLRP3 inflammasome is characterized by recurrent epis...

Introduction Patients with unexplained recurrent febrile episodes and CASP1 variants suffer from systemic sterile inflammation despite reduced secretion of IL-1ß. As previously demonstrated by our group CASP1 variants lead to reduced enzymatic activity of procaspase-1 by destabilizing the tertiary structure of the caspase-1 tetramer. A possible explanation for an alternative pro-inflammatory pa...

BACKGROUND/OBJECTIVES Ambient air pollution can alter cytokine concentrations as shown in vitro and following short-term exposure to high air pollution levels in vivo. Exposure to pollution during late pregnancy has been shown to affect fetal lymphocytic immunophenotypes. However, effects of prenatal exposure to moderate levels of air pollutants on cytokine regulation in cord blood of healthy i...

Biochemistry of Spinal Pain Background Context: Cytokines and neuropeptides are involved in the nervous system response and their role in pain is only beginning to be understood and incorporated into routine care. We present here a review on several cytokines and neuropeptides that might be implicated in spinal pain as well as the future directions of this field of research. Purpose: A review o...