نتایج جستجو برای: il 31
تعداد نتایج: 283590 فیلتر نتایج به سال:
We examined the effect of prostaglandin D2 (PGD2) on IL-31-induced alloknesis in mice. We investigated itch-associated scratching behavior (long-lasting scratching: LLS) as an indicator of itching. Topically applied PGD2 and dexamethasone each significantly suppressed IL-31 (acute or repeated administration)-induced LLS. However, neither PGD2 nor dexamethasone suppressed the IL-31 (repeated adm...
Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited i...
The aim of this study was to investigate the clinical and pathological significance of interleukin 31 (IL-31), interleukin 33 (IL-33), and thymic stromal lymphopoietin (TSLP) in serum of patients with asthma and/or rhinitis. The levels of IL-31, IL-33, and TSLP were measured by enzyme-linked immunoadsorbent assays in serum samples from 64 cases of asthma patients, 64 cases of rhinitis patients,...
In addition to their microbiocidal properties, human beta-defensins (hBDs) and cathelicidin LL-37 stimulate a number of mammalian cell activities, including migration, proliferation, and cytokine/chemokine production. Because hBDs and LL-37 cause mast cells to release pruritogens such as histamine and PGs, we hypothesized that these peptides would stimulate the secretion of a novel pruritogenic...
BACKGROUND Kawasaki disease (KD) is known to be associated with T help (Th) 2 reaction and subsequently allergic diseases. Interleukin-31 (IL-31) has also been reported to be involved in Th2 mediated diseases such as allergic diseases. However, the role of IL-31 in KD has not been previously reported. The aim of this study is to investigate whether IL-31 is associated with KD and its clinical o...
Data on interleukin-31 (IL-31) involvement in the patho-genesis of mastocytosis, and its impact on pruritus development in the disease, are limited. The aim of this study was to analyse distinct IL-31 gene polymorphisms in 127 patients (age 0.5-76 years) with mastocytosis and their correlation with clinical presentation, pruritus and serum IL-31 levels. In patients with mastocytosis, the freque...
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