Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B cells, and n...

Chronic inflammation and oxidative stress have been implicated in the pathophysiology of Major Depressive Disorder (MDD), as well as in a number of chronic medical conditions. The aim of this study was to examine the relationship between peripheral inflammatory and oxidative stress markers in un-medicated subjects with MDD compared to non-depressed healthy controls and compared to subjects with...

BACKGROUND The control of the systemic inflammatory response taking place during cardiac operations depends on adequate antiinflammatory reaction. In this prospective study we tested the hypothesis that cytokine balance during pediatric cardiac surgical procedures would be influenced by the patients' preoperative clinical condition, defined as hypoxemia or heart failure. METHODS Twenty infant...

This study aims to investigate NK cell number and cytokines level in various degrees of severity COVID-19 cases. A total 63 patient aged >18 y were divided into mild-moderate severe-critical groups. Patient characteristics peripheral blood count obtained from medical records. cells number, levels IFN-?, IL-10, IL-12 examined by means flow cytometry. The group had leukocytosis, neutrophilia, ...

Despite existing studies on pathogenetic role of cytokine (CK) system in lung damage pneumonia, there are still controversial issues cytokine-mediated processes that lead to the prolongation inflammatory process tissue this pathology. The article presents study profile bronchoalveolar secretion (BAS) prolonged course community-acquired pneumonia (CAP). To achieve purpose research, patients with...