نتایج جستجو برای: il7r
تعداد نتایج: 206 فیلتر نتایج به سال:
In mammals, the cytokine IL-7 is a key regulator of various aspects of lymphocyte differentiation and homeostasis. Because of the difficulty of identifying cytokine homologs in lower vertebrates and the paucity of assay systems and reagents, the degree of functional conservation of cytokine signaling pathways, particularly those pertaining to lymphocyte development, is unclear. In this article,...
We investigated the effects of aging on the IL-7–mediated CD8 T-cell survival pathway and of IL-7 therapy on T-cell immunity. Cells expressing IL-7 receptor (IL-7R) high and low were identified in a CD45RA effector memory (EMCD45RA , CD45RA CCR7 ) CD8 T-cell subset. Elderly subjects (65 years and older) had an increased frequency of EMCD45RA IL7R low CD8 T cells, leading to decreased STAT5 phos...
Human soluble interleukin-7 receptor (sIL7R)α circulates in high molar excess compared with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity for IL-7 but does not bind thymic stromal lymphopoietin. Functionally, sIL7Rα competes with cell-associated IL-7 receptor to diminish excessive IL-7 consumption and, thus, enhances the bioactivity of IL-7 when the cyt...
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